Selsept, 250 mg capsules 100 pcs

Mycophenolate Mofetil (MMF) is a 2-morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressant, an inosine monophosphate dehydrogenase inhibitor. MMF is a potent, selective noncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) that inhibits the de novo synthesis of guanosine nucleotides. The mechanism by which MFC suppresses the enzymatic activity of IMPDH appears to be related to the fact that MFC structurally mimics both the nicotinamide dinucleotide phosphate cofactor and the catalyzing water molecule. This prevents the oxidation of IMF into xanthose-5-monophosphate, a crucial step in guanosine nucleotide biosynthesis de novo. MMF has a more pronounced cytostatic effect on lymphocytes than on other cells, since the proliferation of T- and B-lymphocytes is very much dependent on the synthesis of purines de novo, while cells of other types can switch to bypass metabolic pathways.

Indications

Adults and children with a body surface area >1.25 m2 (approximate age 12 years):

Adults:

Selsept is prescribed as combination therapy with cyclosporine and corticosteroids.

Active ingredient

How to take, the dosage

Interaction

Special Instructions

Contraindications

With caution: Gastrointestinal diseases (acute phase), concomitant administration of MMF with tacrolimus, sirolimus, with drugs that affect hepatic-intestinal recirculation.

Side effects

Overdose

Data on MMF overdose have been reported in clinical trials and during post-registration use. No adverse events have been reported in most cases. In case of overdose, no adverse events in addition to those described below have been identified.

It is expected that overdose of MMF is likely to lead to excessive immunosuppression (resulting in increased susceptibility to infections) and bone marrow suppression. If neutropenia develops, administration of Selsept should be discontinued or the dose of the drug reduced. MFC cannot be removed from the body by hemodialysis. However, at high plasma concentrations (>100 µg/ml) small amounts of MFKG are still eliminated. Drugs that bind bile acids, such as colestyramine, can help eliminate MFKH from the body by increasing its excretion.

Pregnancy use