Schinoren, 15% gel 50 g

Pharmaceutical group:

A drug with antiproliferative and antibacterial action for the treatment of acne, hyperpigmentation and rosacea.

Pharmic action:

Skinoren is an acne treatment.
Azelaic acid normalizes the disturbed keratinization processes in the follicles of the sebaceous glands, reduces the content of free fatty acids in the skin lipids and reduces the oiliness of the skin.

It has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. Its anti-inflammatory effect is also due to a decrease in neutrophil metabolism and the production of free-radical oxygen forms. Azelaic acid has a dose- and time-dependent suppressive effect on the growth and viability of abnormal melanocytes.

Pharmacokinetics:

Intake
Azelaic acid is virtually not absorbed into the systemic bloodstream after application to the skin (no more than 3.6% in a single application of 5 g of gel or cream).

Elimination
Part of the absorbed azelaic acid is excreted unchanged by the kidneys, and part of it as dicarboxylic acid (C7, C5) formed from azelaic acid by beta-oxidation.

Indications

– acne (acne vulgaris);
– rosacea.

Active ingredient

Composition

1 g of gel for external use contains:

active ingredient:

azelaic acid (micronized) – 0.15 g.

Auxiliary substances:

propylene glycol,

polysorbate 80,
.

lecithin,

polyacrylic acid,

triglycerides,

sodium hydroxide,

dinatrium edetate,

benzoic acid,

purified water.

How to take, the dosage

Externally. Before applying the gel, the skin should be thoroughly washed with water or mild cosmetic cleanser, then dried.

The gel is applied thinly to the affected areas of the skin twice a day (morning and evening) and lightly rubbed in.

Approximately 2.5 cm of the gel is enough for the entire surface of the face. It is important that Schinoren is used regularly throughout the treatment period.

The duration of application of Skynoren is individual and depends on the severity of the disease. Improvement usually occurs after 4 weeks of treatment. However, to achieve the best results, it is necessary to use Skinoren gel for several months.

Interaction

Skinoren can be used in combination with other acne therapies.

The dosing regimen of concomitant medications may be adjusted.

Special Instructions

The product is for external use only.

Avoid contact of the drug with eyes and wound surfaces.

In case of accidental contact with eyes or wound surfaces, rinse thoroughly with warm water.

Epidermal and mixed epidermal-dermal types of melasma are well treated with Schinoren.

Dermal melasma, on the other hand, is not treatable with Skynoren. For differential diagnosis, the use of a Wood lamp is recommended.

Contraindications

Hypersensitivity to the components of Skynoren.

Side effects

In the beginning of treatment, local irritation, skin hyperemia and peeling, burning, erythema, itching are rare.

In most cases the side effects are mild, cease during treatment and do not require discontinuation of the drug.

In very rare cases, allergic skin reactions (e.g., rash) may occur

In case of skin irritation, reduce the single application of the drug or reduce the frequency of use to once a day.

If necessary, treatment may have to be temporarily interrupted for several days.

Overdose

Animal studies have shown no risk of acute intoxication from a single overdose when applied topically or ingested.

Pregnancy use

The use of the drug during pregnancy and lactation is possible after approval of the doctor, but it is necessary to avoid applying it to the mammary gland area before lactation.

Similarities