Salofalc, rectal suspension 2 g/30 ml 30 ml 7 pcs.

It has a local anti-inflammatory effect due to inhibition of cyclooxygenase and synthesis of PG and leukotrienes. It inhibits migration, degranulation, phagocytosis of neutrophils as well as immunoglobulin secretion by lymphocytes.

Indications

Exacerbation of distal forms of ulcerative colitis of moderate and mild severity; maintenance of remission of distal forms of ulcerative colitis (long-term therapy).

Active ingredient

Mesalazine

Composition

1 enema contains:

Active substance:

Mesalazine 2 g/30 ml;

Associates:

Purified water;

Potassium acetate;

Potassium disulfite;

xanthan gum;

carbomer;

sodium benzoate;

sodium ethylaminoacetate;

Nitrogen gas.

How to take, the dosage

The contents of one reservoir are administered rectally once a day before going to bed (it is recommended to clean the bowels beforehand). The daily dose is 30-50 mg/kg.

The maximum daily dose is 3 g.

The oral administration of Salofolk as tablets at a dose of 15-30 mg/kg/day is recommended to prevent relapses. The daily dose should be divided into 2 doses.

Interaction

Concomitant administration may increase the effect of coumarin anticoagulants, increased toxicity of methotrexate, decreased diuretic effect of spironolactone and furosemide, reduced effectiveness of probenecid and rifampicin.

Special Instructions

Salofalc is recommended to be used only under the supervision of a doctor.

Contraindications

• hypersensitivity to the drug components and other salicylic acid derivatives;
• blood diseases;
• duodenal and gastric ulcer;

.

• glucose-6-phosphate dehydrogenase deficiency;
• hemorrhagic diathesis;
• severe renal/liver failure;
• childhood (under 6 years);
• phenylketonuria.

With caution: pregnancy (1st trimester), mild to moderate renal/liver failure, lung diseases (especially bronchial asthma).

Side effects

Gastrointestinal disorders: diarrhea, nausea, abdominal pain, flatulence, loss of appetite, vomiting, increased level of liver enzymes in blood, hepatitis.

CNS disorders: headache, depression, dizziness, sleep disturbance, malaise, paresthesias, seizures, tremors, tinnitus.

Reactions associated with hypersensitivity: skin rash, itching, erythema, fever, bronchospasm, pericarditis and myocarditis, acute pancreatitis, interstitial nephritis, nephrotic syndrome.

In isolated cases of allergic alveolitis and pancolitis have been observed. Under certain conditions, mesalazine and drugs with a similar chemical structure may lead to the development of a syndrome similar to systemic lupus erythematosus.

Other side effects: rarely – tachycardia, arterial hypertension or hypotension, pain behind the chest, shortness of breath; myalgia, arthralgia. In individual cases proteinuria, hematuria, crystalluria, oliguria, anuria; anemia, leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia; decreased tear fluid production, alopecia.

Overdose

Symptoms: nausea, vomiting, weakness, drowsiness.

Treatment: symptomatic therapy.

Similarities

Salofalc, Mesacol, Mesalazine, Mesavant, Cansalazine