Salofalc, 500 mg 50 pcs.

It has a local anti-inflammatory effect due to inhibition of cyclooxygenase and synthesis of PG and leukotrienes. It inhibits migration, degranulation, phagocytosis of neutrophils as well as immunoglobulin secretion by lymphocytes.

Indications

Active ingredient

Composition

1 tablet contains:

The active ingredient:

mesalazine500 mg;

Associates:

Sodium carbonate;

MCC;

povidone;

croscarmellose;

How to take, the dosage

The drug is used strictly on prescription.

Overly, whole, without chewing, after a meal, with plenty of water.

Adults: 500 mg (2 tablets of 250 mg or 1 tablet of 500 mg) 3 times a day. In severe forms of the disease the dose can be increased to 3-4 g/day for 8-12 weeks.

To prevent recurrences, the drug is prescribed 500 mg (2 tablets of 250 mg or 1 tablet of 500 mg) 3 times a day, if necessary, for several years.

In children. For body weight up to 40 kg half the daily dose for adults (1 tablet of 250 mg 3 times a day), over 40 kg the daily dose for adults (2 tablets of 250 mg or 1 tablet of 500 mg) 3 times a day is prescribed.

To prevent relapses, the drug is prescribed 250 mg 3 times daily, if necessary for several years.

In distal forms of nonspecific ulcerative colitis it is preferable to administer the drug rectally in the form of suppositories or enemas.

Interaction

Special Instructions

Contraindications

With caution: pregnancy (1st trimester), mild to moderate renal/liver failure, lung diseases (especially bronchial asthma).

Side effects

Gastrointestinal disorders: diarrhea, nausea, abdominal pain, flatulence, loss of appetite, vomiting, increased level of liver enzymes in blood, hepatitis.

CNS disorders: headache, depression, dizziness, sleep disturbance, malaise, paresthesias, seizures, tremors, tinnitus.

Reactions associated with hypersensitivity: skin rash, itching, erythema, fever, bronchospasm, pericarditis and myocarditis, acute pancreatitis, interstitial nephritis, nephrotic syndrome.

In isolated cases of allergic alveolitis and pancolitis have been observed. Under certain conditions, mesalazine and drugs with a similar chemical structure may lead to the development of a syndrome similar to systemic lupus erythematosus.

Other side effects: rarely – tachycardia, arterial hypertension or hypotension, pain behind the chest, shortness of breath; myalgia, arthralgia. In individual cases proteinuria, hematuria, crystalluria, oliguria, anuria; anemia, leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia; decreased tear fluid production, alopecia.

Overdose

Symptoms: nausea, vomiting, weakness, drowsiness.

Treatment: symptomatic therapy.

Similarities