Rosuvastatin-Vertex, 20 mg 30 pcs
€23.05 €19.97
Rosuvastatin is a selective competitive inhibitor of HMG-CoA reductase – an enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A into mevalonic acid, a precursor of cholesterol.
Indications
– Primary hypercholesterolemia according to the Fredrickson classification (type IIa, including familial heterozygous hypercholesterolemia) or mixed hypercholesterolemia (type IIb) as an adjunct to diet when diet and other non-drug treatments (eg, exercise, weight loss) are insufficient;
Pharmacological effect
Rosuvastatin is a selective competitive inhibitor of HMG-CoA reductase, an enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A into mevalonic acid, a cholesterol precursor.
Special instructions
Renal dysfunction. In patients receiving high doses of rosuvastatin (particularly 40 mg/day), tubular proteinuria was observed, which was detected using test strips and in most cases was intermittent or short-term. Such proteinuria does not indicate acute illness or progression of concomitant renal disease.
Active ingredient
Rosuvastatin
Composition
Light pink to pink film-coated tablets, round, biconvex;
Pregnancy
Rosuvastatin is contraindicated during pregnancy and lactation. Women of reproductive age should use adequate methods of contraception.
Contraindications
Daily dose up to 30 mg: hypersensitivity to rosuvastatin; liver diseases in the active phase (including a persistent increase in the activity of liver transaminases and an increase in the activity of liver transaminases in the blood serum by more than 3 times compared to ULN); severe renal failure (Cl creatinine Daily dose 30 mg or more: hypersensitivity to rosuvastatin;
Side Effects
Side effects observed with the use of rosuvastatin are usually mild and go away on their own. As with other HMG-CoA reductase inhibitors, the incidence of side effects is mainly dose-dependent.
Interaction
Transport protein inhibitors: rosuvastatin binds to some transport proteins, in particular OATP1B1 and BCRP. Concomitant use of drugs that are inhibitors of these transport proteins may be accompanied by an increase in the concentration of rosuvastatin in the blood plasma and an increased risk of developing myopathy.
Overdose
Symptoms: the clinical picture of overdose has not been described.
Recommendations for use
Inside, do not chew or crush the tablet, swallow it whole with water.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C.
Shelf life
2 years
Manufacturer
Vertex, Russia
Shelf life | 2 years |
---|---|
Conditions of storage | Store in a dark place at a temperature not exceeding 25 ° C. |
Manufacturer | Vertex, Russia |
Medication form | pills |
Brand | Vertex |
Other forms…
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