Rosinsulin C, 100 me/ml suspension 3 ml cartridges 5 pcs

Rosinsulin C is human insulin produced using recombinant DNA technology. It is a medium-acting insulin preparation. It interacts with specific receptor of outer cytoplasmic cell membrane and forms insulin-receptor complex, which stimulates intracellular processes, including synthesis of several key enzymes (hexokinase, pyruvate kinase, glycogen synthetase and others).

Decrease of glucose content in blood is caused by increase of its intracellular transport, increase of absorption and assimilation by tissues, stimulation of lipogenesis and glycogenogenesis, decrease of glucose production by liver and others. The duration of action of insulin drugs is mainly due to the speed of absorption, which depends on several factors (e.g., the dose, route and place of administration), so the action profile of insulin is subject to significant variations, both in different people and in the same person.

The profile of action when injected subcutaneously (approximate figures): onset of action in 1-2 hours, maximum effect between 6 and 12 hours, duration of action 18-24 hours.

Indications

How to take, the dosage

Rosinsulin C is intended for subcutaneous administration. The dose of the drug is determined by the doctor individually in each case, based on the level of glucose in the blood. The average daily dose of the drug ranges from 0.5 IU/kg to 1 IU/kg body weight (depending on the individual patient and the blood glucose level).

The temperature of the administered insulin should be at room temperature.

Rosinsulin C is usually injected subcutaneously in the thigh. It can also be injected into the anterior abdominal wall, gluteus, or deltoid region of the upper arm.

It is necessary to change the injection sites within the anatomical area to prevent the development of lipodystrophy.

Rosinsulin C can be given alone or in combination with short-acting insulin (Rosinsulin R).

When using prefilled single-dose multi-dose syringe pens for multiple injections, the syringe must be removed from the refrigerator before the first use and the drug must be allowed to reach room temperature. Rosinsulin C in a disposable syringe pen must not be used if it has been frozen. Follow precisely the instructions for use of the syringe pen supplied with the product.

Interaction

There are a number of medications that affect the need for insulin.

Special Instructions

Check the appearance of the contents of the vial carefully before each use and DO NOT USE Rosinsulin C if the suspension contains flakes after shaking or if particles of white have adhered to the bottom or walls of the vial, creating a frosty pattern.

Persistent Rosinsulin C should not be used if the suspension does not turn white and uniformly turbid after shaking.

With insulin therapy, continuous monitoring of blood glucose levels is necessary.

The causes of hypoglycemia in addition to insulin overdose may be: changing the drug, skipping meals, vomiting, diarrhea, increased physical activity, diseases that reduce the need for insulin (liver and kidney function disorders, adrenal, pituitary or thyroid hypofunction), change of injection site, and interaction with other medications.

Inadequate dosing or intermittent insulin administration, especially in patients with Type I diabetes, can lead to hyperglycemia. Usually the first symptoms of hyperglycemia develop gradually over a few hours or days. They include the appearance of thirst, increased frequency of urination, nausea, vomiting, dizziness, red and dry skin, dry mouth, loss of appetite, and the smell of acetone in the exhaled air. If left untreated, hyperglycemia in type 1 diabetes can lead to life-threatening diabetic ketoacidosis.

The insulin dose should be adjusted for thyroid dysfunction, Addison’s disease, hypopituitarism, hepatic and renal dysfunction, and diabetes mellitus in individuals over age 65.

The insulin dose may also need to be adjusted if the patient increases physical activity or changes their diet.

Concomitant diseases, especially infections and conditions with fever, increase the need for insulin.

Transition from one type of insulin to another should be done under control of blood glucose levels.

The drug reduces alcohol tolerance.

Due to the potential for precipitation in some catheters, use of the drug in insulin pumps is not recommended.

Contraindications

– Hypersensitivity to insulin or any of the ingredients of the drug;

– Hypoglycemia.

Side effects

Associated effects on carbohydrate metabolism: hypoglycemic states (pale skin, increased sweating, palpitations, tremors, hunger, agitation, paresthesias in the mouth, headache). Severe hypoglycemia may lead to hypoglycemic coma.

Allergic reactions: rare – skin rash, Quincke’s edema; very rare – anaphylactic shock.

Local reactions: hyperemia, swelling and itching at the injection site; with long-term use – lipodystrophy at the injection site.

Others: edema, transient refractive disorders (usually at the beginning of therapy).

Overdose

Hypoglycemia may occur in overdose.

Treatment: Mild hypoglycemia can be treated by the patient himself by taking sugar or carbohydrate-rich foods. Therefore, it is recommended that diabetics carry sugar, sweets, cookies, or sweet fruit juice with them at all times.