Rinza, tablets 4 pcs
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Combined drug.
Paracetamol has analgesic and antipyretic effect. It reduces the pain syndrome observed during colds – sore throat, headache, muscle and joint pain, reduces fever.
Phenylephrine is an alpha 1-adrenomimetic. It has a vasoconstrictor effect, decreases edema and hyperemia of mucous membranes of upper airways and sinuses.
Chlorphenamine is a blocker of histamine H1-receptors, has anti-allergic effect, reduces swelling and hyperemia of mucous membranes of the nasal cavity, nasopharynx and accessory sinuses, eliminates eye and nose itching, reduces exudative symptoms.
Caffeine has a stimulating effect on the CNS, resulting in decreased fatigue and drowsiness, increased mental and physical performance.
Indications
Sneezing, Headache, Flu, Runny nose (rhinitis), Cold, Muscle pain (myalgia), Temperature, Sore throat, stuffy noseSymptomatic treatment of “colds”, SARS, including flu (fever, pain syndrome, rhinorrhea).
Active ingredient
Caffeine, Paracetamol, Phenylephrine, Chlorphenamine
Composition
1 tablet contains:
Active ingredients:
Caffeine ………………………………………….30 mg
Paracetamol ………………………………….500 mg
Phenylephrine hydrochloride……………………10 mg
Chlorphenamine maleate …………………………..2 mg
Excipients: colloidal silica, corn starch, corn starch (for 20% paste), povidone (K30), sodium methyl parahydroxybenzoate, magnesium stearate, talc, sodium carboxymethyl starch (type A), crimson dye [Ponceau 4R].
How to take, the dosage
Orally.
Children over 15 years of age and adults – 1 tablet 3 – 4 times a day.
Maximal daily dose – 4 tablets.
Course of treatment not more than 5 days.
Interaction
Increases the effects of monoamine oxidase inhibitors (MAOIs), sedatives, ethanol.
Antidepressants, antiparkinsonian drugs, antipsychotics, phenothiazine derivatives – increase the risk of urinary retention, dry mouth, constipation.
Glucocorticosteroids increase the risk of glaucoma. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects.
Metoclopramide and domperidone increase, and colestyramine reduces the absorption rate of paracetamol. Paracetamol reduces the effectiveness of uricosuric drugs.
When concomitantly prescribed with barbiturates, diphenin, carbamazepine, rifampicin isoniazid, zidovudine and other inducers of microsomal liver enzymes, the risk of hepatotoxic effects of paracetamol increases.
When chloramphenicol and paracetamol are used together, the half-life of chloramphenicol may increase.
In most patients taking long-term warfarin, infrequent paracetamol use generally has little or no effect on the international normalized ratio (INR). However, with prolonged regular use, paracetamol increases the effect of indirect anticoagulants (warfarin and other coumarin derivatives), which increases the risk of bleeding.
A single large dose of caffeine contributes to increased renal excretion of lithium. Abrupt cessation of caffeine intake may lead to increased serum lithium concentration.
Chlorphenamine concomitantly with monoamine oxidase inhibitors (MAOIs), furazolidone may lead to hypertensive crisis, agitation, hyperpyrexia.
Concomitant use of phenylephrine with digoxin and other cardiac glycosides may increase the risk of arrhythmia and myocardial infarction.
Phenylephrine when taken with MAO inhibitors may lead to increased blood pressure. Phenylephrine reduces the effectiveness of beta-blockers and antihypertensive drugs.
Tricyclic antidepressants increase the adrenomimetic effect of phenylephrine, simultaneous administration of halothane increases the risk of ventricular arrhythmia. It reduces the hypotensive effect of guanethidine, which in turn enhances the alpha-adrenomimetic activity of phenylephrine.
Special Instructions
During treatment, you should refrain from taking alcohol, sleeping pills and anxiolytics (tranquilizers). Do not take together with other drugs containing paracetamol.
If the symptoms of the disease worsen or persist after 5 days of using the drug, you should stop taking it and consult your doctor.
The drug may cause drowsiness.
If the drug has expired or expired – do not throw it in the sewage or on the street! Place the medication in a bag and put it in a trash container. These measures will help protect the environment!
Synopsis
Round, flat, pink tablets with dark pink and white flecks, with beveled edges and a separating ridge on one side.
Contraindications
- expressed coronary atherosclerosis;
- arterial hypertension;
- portal hypertension;
- diabetesdiabetes mellitus;
- current use of tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), beta-adrenoblockers;
- Having taken other drugs containing substancestaking other drugs containing substances in Rinza®;
- pregnancy, lactation;
- childhood (under 15 years);
- alcoholism.
.
Side effects
Allergic reactions: skin rash, itching, urticaria, angioedema, anaphylactic shock.
Nervous system: headache, dizziness, drowsiness, trouble falling asleep, increased excitability.
Cardiovascular system: increase in blood pressure, tachycardia, palpitations.
Digestive system: nausea, vomiting, epigastric pain, diarrhea, dry oral mucosa, hepatotoxic effect.
Senses: mydriasis, accommodation paresis, increased intraocular pressure.
Blood organs: anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, leukopenia.
Urinary system: nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis), difficulty in urination.
Other: bronchospasm.
Serious skin reactions:
Very rare:
– Acute generalized exanthematous pustulosis (OGEP). An acute condition with the development of pustular rashes. It is characterized by fever and diffuse erythema accompanied by burning and itching. Edema of the face, hands and mucous membranes may occur;
– Stevens-Johnson syndrome (SJS) (malignant erythema exudative). A severe form of erythema multiforme with blisters on the mucosa of the mouth, throat, eyes, genitals, other areas of the skin and mucous membranes.
– Toxic epidermal necrolysis (TEN, Lyell’s syndrome). The syndrome is a consequence of extensive apoptosis of keratinocytes, which leads to the detachment of large areas of skin at the dermoepidermal junction. Affected skin has the appearance of scalded with boiling water.
If you notice one of the above side effects you should stop taking the drug and immediately contact your doctor!
Overdose
In the case of an overdose, seek medical attention immediately. Prompt medical attention is critical, even if you do not observe any signs or symptoms.
- Caffeine
Symptoms of acute overdose: abdominal pain, vomiting, flashes of blood to the face, fever, chills, agitation, insomnia, irritability, loss of appetite, weakness, tremor, increased muscle tone, altered state of consciousness, delirium, hallucinations, increased blood pressure followed by hypotension, tachycardia, tachypnoea, increased diuresis, hypokalemia, hyponatremia, hyperglycemia, metabolic acidosis, seizures, myoclonias and rhabdomyolysis, supraventricular and ventricular arrhythmias.
Symptoms of chronic caffeine intoxication “caffeinism”: irritability, insomnia, anxiety, emotional lability, chronic abdominal pain.
- Chlorphenamine
Symptoms: CNS depression, hyperthermia, anticholinergic syndrome (mydriasis, facial flushes, fever dry mouth, urinary retention, bowel paresis), tachycardia, hypotension, hypertension, nausea, vomiting, agitation, disorientation, hallucinations, psychosis, seizures, arrhythmias. Rarely, patients with agitation, seizures or patients in coma develop rhabdomyolysis and renal failure.
- Phenylephrine
Symptoms: nausea, vomiting, irritability, agitation, insomnia, psychosis, seizures, palpitations, tachycardia, increased blood pressure, reflex bradycardia.
- Paracetamol
Symptoms that occur after taking more than 7.5 – 10 g: Within the first 24 h after ingestion – pallor of the skin, nausea, vomiting; anorexia, abdominal pain; increased prothrombin time, impaired glucose metabolism, metabolic acidosis (incl.
Symptoms of liver function abnormalities may appear 12 – 48 hours after overdose: increase of liver transaminases activity, hepatonecrosis. In severe cases – hepatic failure with progressive encephalopathy, coma. Rarely, liver failure develops fulminantly and may be complicated by renal failure (tubular necrosis).
The threshold of overdose may be lowered in elderly patients and children, in patients taking certain drugs (eg, inducers of microsomal liver enzymes), alcohol or suffering from exhaustion.
Treatment: gastric lavage, administration of activated charcoal during the first 6 hours after overdose, administration of SH-group donators and glutathione synthesis precursors – methionine in 8-9 hours after overdose and acetylcysteine in 12 hours. The need for additional therapeutic measures (further administration of methionine and acetylcysteine) is determined by the concentration of paracetamol in blood, as well as the time elapsed after its administration. Symptomatic therapy.
Pregnancy use
In the absence of clinical data, the safety of using the drug during pregnancy and breastfeeding has not been established, so the drug is contraindicated for this category of patients.
Similarities
Rinicold
Weight | 0.010 kg |
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Shelf life | 3 years. |
Conditions of storage | Store out of the reach of children, dry, protected from light at a temperature not exceeding 25°C. |
Manufacturer | Unique Pharmaceutical Laboratories, India |
Medication form | pills |
Brand | Unique Pharmaceutical Laboratories |
Other forms…
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