Rekognan, 100 mg/ml 30 ml

Pharmacological group:

Notropic drug

Pharmacotherapeutic group:

Notropic drug

Pharmacological action

Citicoline, as a precursor of the key ultrastructural components of the cell membrane (mainly phospholipids), has a broad spectrum of action: promotes repair of damaged cell membranes, inhibits the action of phospholipases, preventing excessive formation of free radicals, and also prevents cell death by acting on apoptosis mechanisms.

In the acute period of stroke it reduces the volume of damaged tissue, improves cholinergic transmission.

In brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms, and also helps to reduce the duration of the recovery period.

Cyticoline is effective in the treatment of cognitive, sensory and motor neurological disorders of degenerative and vascular etiology.

In chronic cerebral ischemia, citicoline is effective in the treatment of disorders such as impaired memory, lack of initiative, difficulty in performing daily activities and self-care. It increases the level of attention and consciousness and reduces the manifestation of amnesia.

Pharmacokinetics

Absorption

Cyticolin is well absorbed when taken orally. Absorption after oral administration is almost complete and bioavailability is approximately the same as after IV administration. After oral administration and parenteral administration the plasma concentration of choline is significantly increased.

Distribution

Cyticoline is largely distributed in brain structures, with rapid incorporation of choline fractions into structural phospholipids and citidine fractions into citidine nucleotides and nucleic acids. Citicoline penetrates the brain and is actively incorporated into cellular, cytoplasmic and mitochondrial membranes, forming part of the structural phospholipids fraction.

Metabolism

In IV and IM administration citicoline is metabolized in the liver to form choline and citidine.

Elimination

Only 15% of the administered dose of citicoline is excreted from the human body: less than 3% by the kidneys and intestines and about 12% through the exhaled air.

Two phases can be distinguished in the urinary excretion of citicoline: the first phase, lasting about 36 hours, during which the excretion rate decreases rapidly, and the second phase, during which the excretion rate decreases much more slowly. The same is observed in exhaled air – the excretion rate drops rapidly after about 15 h and then decreases much more slowly.

Indications

– Acute period of ischemic stroke (as part of complex therapy);

– The recovery period of ischemic and hemorrhagic strokes;

– craniocerebral trauma (CTS), acute (as part of complex therapy) and recovery period;

– cognitive and behavioral disorders in degenerative and vascular diseases of the brain.

Active ingredient

Composition

The oral solution is clear, colorless, with a characteristic strawberry odor.

Associates:

sorbitol – 20 g,

glycerol – 5 g,

methyl parahydroxybenzoate – 0.145 mg,

propyl parahydroxybenzoate – 0.025 mg,

potassium sorbate – 0.3 g,

sodium citrate dihydrate – 0.6 g,

sodium saccharinate – 0.02 g,

Strawberry flavoring FRESA S.1487S – 0.04 g,

citric acid – to pH 6.0,

purified water – up to 100 ml.

How to take, the dosage

Special oral solution

Take with meals or between meals. Before use, the drug may be diluted in a small amount of water (120 ml or 1/2 cup).

Acute period of ischemic stroke and traumatic brain injury: 1000 mg (10 ml or 1 sachet) every 12 hours. The duration of treatment is at least 6 weeks.

Restorative period of ischemic and hemorrhagic strokes, restorative period of ChMT, cognitive and behavioral disorders in degenerative and vascular brain diseases: 500-2000 mg/day (5-10 ml 1-2 times/day or 1 sachet 1-2 times/day). The dose and duration of treatment are established depending on the severity of the symptoms.

Dose adjustment is not required in elderly patients.

Instructions for use of the dispensing pipette supplied with the bottle

1. Place the dispensing pipette into the bottle (pipette piston fully down).

2. Gently pull the dispensing pipette piston until the solution level is aligned with the marking on the pipette.

3. Before dosing, the desired amount of solution can be diluted in 1/2 cup of water (120 ml).

After each use, it is recommended to rinse the dispensing pipette with water.

Recommendations for use of Recognan® in sachets

1. Take a sachet of Recognan® 1000 mg by the edge and shake.

Tear off the edge of the bag at the point marked with the dotted line.

3. drink the contents of the sachet immediately after opening.

4. or dissolve it in 1/2 cup of drinking water (120 ml) and drink it.

Interaction

Citicoline enhances the effects of levodopa.

Do not prescribe concomitantly with drugs containing meclofenoxate.

Special Instructions

A small amount of crystals may form in the oral solution when refrigerated due to temporary partial crystallization of the preservative. Upon further storage under recommended conditions the crystals dissolve within several months. The presence of crystals does not affect the quality of the product.

Impact on driving and operating machinery

Patients should be careful during treatment when performing potentially hazardous activities requiring increased attention and quick psychomotor reactions (including driving vehicles, operating moving machinery, operator’s work).

Contraindications

– vagotonia (predominance of tone of the parasympathetic part of the autonomic nervous system);

– rare hereditary diseases associated with fructose intolerance (for oral administration);

– childhood and adolescence under 18 years of age (due to lack of clinical data);

– hypersensitivity to the components of the drug.

There is no information about the relative contraindications for oral use of the drug.

Side effects

Frequency of adverse reactions: very rare (less than 1/10 000) (including individual cases).

Allergic reactions: rash, skin itching, anaphylactic shock.

Nervous system disorders: headache, dizziness, insomnia, agitation, hallucinations. In some cases the drug may stimulate the parasympathetic system and change BP for a short time.

Digestive system disorders: nausea, vomiting, diarrhea, decreased appetite, altered liver enzyme activity.

General reactions: fever, tremor, shortness of breath, numbness in paralyzed limbs, edema.

If any of these side effects are worsened or any other side effects are noted, the patient should inform the physician.

Overdose

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