Reglisam for children, 25 mg 30 pcs

Respiratory tract diseases with difficult to remove sputum, including mild bronchial asthma (in the treatment).

Active ingredient

Ammonium Glycyrrhizinate

How to take, the dosage

Orally 30 minutes after the meal in the form of an aqueous solution, which is prepared before use by dissolving the contents of one bag (1.3 g) in 1 tablespoon (15 ml) of warm boiled water (single dose).
The drug is prescribed to children according to age:

• from 5 months to 3 years – 2 times a day;
• from 3 to 5 years – 3 times a day;
• from 5 to 10 years – 3-4 times a day.

The course of treatment – from 3 to 30 days. Repeated courses are possible by agreement with the doctor. Children over 10 years of age are prescribed Glycyram in the form of tablets of 50 mg.

Interaction

It is possible to intensify the action of drugs stimulating the function of the adrenal cortex.

Special Instructions

Diabetics and those on a reduced carbohydrate diet should be aware that one packet of the product contains about 1.22 grams of carbohydrates (0.1 IU).

Synopsis

Granules for preparation of solution for oral administration (orange) are white, homogeneous, without agglomerates, with a smell of orange.

Features

Absorption and distribution

Absorption is high. Bioavailability when administered orally is 10%, which is due to the pronounced effect of “first passage” through the liver. Time to reach C_max in blood plasma is 1-3 hours.

The binding to plasma proteins is 50%. It penetrates through the placental barrier. There is no data on the ability of acetylcysteine to penetrate through the BBB and excreted with breast milk.

Metabolism and excretion

It is quickly metabolized in the liver to form pharmacologically active metabolite – cysteine, as well as diacetylcysteine, cystine and mixed disulfides.

Extracted by the kidneys as inactive metabolites (inorganic sulfates, diacetylcysteine). T_1/2 is about 1 hour.

Pharmacokinetics in special clinical cases

Hepatic impairment leads to prolongation of T_1/2 to 8 h.

Contraindications

Hypersensitivity to the drug components, severe organic lesions of the heart and parenchymal organs, liver and kidney function disorders, age under 5 months, lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Side effects

Allergic reactions are possible.

Overdose

Possible liver dysfunction.

Similarities

Epigen Intim