Rederm ointment, ointment 15 g

A combination drug for external use, the action of which is due to its constituent components; the drug has anti-inflammatory, anti-allergic, antipruritic, keratolytic effect.

Betamethasone inhibits release of inflammatory mediators, prevents edge accumulation of neutrophils, reduces inflammatory exudate and cytokines production, decreases macrophages migration resulting in reduction of infiltration and granulation processes.

Owing to the presence of salicylic acid, it softens the skin, eliminates stratum corneum and promotes deeper penetration of betamethasone.

Indications

Therapy of subacute and chronic dermatoses accompanied by hyperkeratosis and peeling:

– psoriasis;
– dyshidrotic dermatitis;
– eczema;
– neurodermitis;
– red squamous lichen;
– Ichthyosis and ichthyosis skin lesions;
– Atopic dermatitis;
– Diffuse neurodermitis;
– Simple and allergic dermatitis;
– urticaria;
– erythema multiforme;
– simple chronic lichen (limited neurodermitis);
– dermatoses that cannot be treated with other GCS (especially red warts);
– skin dyshydrosis.

Active ingredient

Composition

100 g of the ointment contain:

the active ingredients:

betamethasone dipropionate in terms of betamethasone – 0.05 g,

salicylic acid – 3.0 g;

excipients:

liquid paraffin (petroleum jelly),

Vaseline (white petroleum jelly, white soft paraffin).

How to take, the dosage

Externally.

Applied to the affected areas at the rate of: 0.5 cm long column of ointment on an area of the skin about 7 × 7 cm, rubbing lightly, in a thin layer, 2 times a day. Other frequency of use may be determined by the doctor, based on the severity of the disease. In mild cases, the ointment is usually sufficient once a day; in more severe lesions, more frequent application may be necessary.

If necessary, occlusive dressings are applied and changed every 24 hours.

The duration of treatment depends on the effectiveness and tolerability of therapy and is 2-4 weeks.
If there is no clinical improvement, the diagnosis must be clarified.

Special patient groups

Children. In children from 2 years of age the drug is prescribed only under strict indications and under medical supervision because of possible development of systemic side effects associated with betamethasone. The duration of treatment should be as short as possible.

The use of the drug on large surfaces and/or under an occlusive dressing may suppress hypothalamic-pituitary-adrenal system function and develop symptoms of hypercorticism, decreased growth hormone excretion and increased IOP may be observed.

Special Instructions

Avoid contact of the drug with the eyes, do not apply to the skin near the eyes and mucous membranes. The drug is not intended for use in ophthalmology.

In case of prolonged treatment, application of the drug to large areas of skin, use of occlusive dressings, systemic absorption of GCS is possible.

Long-term use on the face is not recommended; rosacea-type dermatitis, perioral dermatitis, skin atrophy and acne are possible; use in the anogenital area should be avoided.

The ointment is most suitable for treating patients with dry and fragile skin.

If signs of skin hypersensitivity or irritation associated with use are noted, treatment should be discontinued and the patient should be appropriately treated.

When using the drug over a long period of time, it should be discontinued gradually.

Contraindications

Hepatic failure; childhood (older than 2 years); prolonged therapy, especially with occlusive dressings.

Side effects

Burning, irritation, dryness, hypopigmentation, skin itching, folliculitis, hypertrichosis, dermatitis, acne-like rashes.

In case of use of occlusive dressings – skin maceration, stricture, skin atrophy, secondary infection, sweating.

Long-term use – skin atrophy, local hirsutism, telangiectasia, purpura, hypopigmentation, hypertrichosis.

. When applied to large surfaces – systemic side effects of GCS (growth retardation, Icenko-Cushing’s syndrome, increased IOP after treatment, hyperglycemia, glucosuria, hypokalemia, increased BP) or salicylates (pallor, increased fatigue, drowsiness, hyperventilation with tachypnea, nausea, vomiting, hearing loss, confusion).

Overdose

Symptoms:

Acute overdose is unlikely, but chronic overdose accompanied by signs of hypercorticism – hyperglycemia, glucosuria, reversible suppression of adrenal cortical function, manifestation of Cushing’s syndrome is possible with excessive or prolonged use of the drug.

Treatment:

Appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual withdrawal of the drug is recommended.

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