Rederm, ointment 30 g

Topical glucocorticosteroid + keratolytic agent

ATEx code: D07XC01

A combination drug for topical use, which action is due to its constituent components; the drug has anti-inflammatory, anti-allergic, antipruritic, keratolytic action. Betamethasone inhibits release of inflammatory mediators, prevents edge accumulation of neutrophils, reduces inflammatory exudate and cytokine production, reduces migration of macrophages which results in reduction of infiltration and granulation processes.

Owing to the presence of salicylic acid it softens the skin, eliminates stratum corneum and promotes deeper penetration of betamethasone.

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Indications

Treatment of subacute and chronic dermatoses accompanied by hyperkeratosis and peeling:

– psoriasis;

– dyshidrotic dermatitis;

– eczema;

— neurodermatitis;

– lichen planus;

– ichthyosis and ichthyotic skin lesions;

– atopic dermatitis;

— diffuse neurodermatitis;

– simple and allergic dermatitis;

– urticaria;

– exudative erythema multiforme;

— simple chronic lichen (limited neurodermatitis);

– dermatoses that cannot be treated with other corticosteroids (especially verrucous verrucous);

– skin dyshidrosis.

Pharmacological effect

Glucocorticosteroid for local use + keratolytic agent

ATX code: D07ХС01

A combined preparation for external use, the effect of which is determined by its constituent components; the drug has anti-inflammatory, antiallergic, antipruritic, keratolytic effects. Betamethasone inhibits the release of inflammatory mediators, prevents the marginal accumulation of neutrophils, reduces inflammatory exudate and the production of cytokines, reduces the migration of macrophages, leading to a decrease in the processes of infiltration and granulation.

Thanks to the presence of salicylic acid, it softens the skin, removes horny layers and promotes deeper penetration of betamethasone.

Special instructions

Avoid contact of the drug with the eyes; do not apply to the skin near the eyes or mucous membranes. The drug is not intended for use in ophthalmology. With prolonged treatment, when applying the drug to large surfaces of the skin, when using occlusive dressings, systemic absorption of glucocorticosteroids is possible.

Long-term use on the skin of the face is not recommended – the development of dermatitis such as rosacea, perioral dermatitis, skin atrophy and acne is possible; Avoid use in the anogenital area.

The ointment is most suitable for treating patients with dry and fragile skin.

If signs of hypersensitivity or skin irritation associated with the use of the drug are observed, treatment should be discontinued and adequate therapy should be selected for the patient.

With long-term use of the drug, its withdrawal should be carried out gradually.

Active ingredient

Betamethasone, Salicylic acid

Composition

100 g:

– betamethasone dipropionate in terms of betamethasone 0.05 g

– salicylic acid 3.0 g

excipients:

liquid paraffin (vaseline oil),

Vaseline (white petroleum jelly, white soft paraffin).

Pregnancy

The safety of topical glucocorticosteroids in pregnant women has not been established. The prescription of this group of drugs during pregnancy is justified only if the potential benefit to the mother outweighs the potential risk to the fetus. During pregnancy, drugs in this group should not be used in high doses or for long periods of time.

It has not been established whether local use of glucocorticosteroids can cause them to appear in mother’s milk, so the issue of stopping breastfeeding should be addressed.

Use in pediatrics

For children over 2 years of age, the drug is prescribed only according to strict indications and under medical supervision, since the development of systemic side effects associated with betamethasone is possible. The duration of treatment should be as short as possible. When using the drug on large surfaces and/or under an occlusive dressing, suppression of the function of the hypothalamic-pituitary-adrenal system and the development of symptoms of hypercortisolism may occur; a decrease in the excretion of growth hormone and an increase in intracranial pressure may be observed.

Contraindications

Children under 2 years of age, lactation period, hypersensitivity, open wounds, bacterial, viral and fungal skin diseases (pyoderma, syphilis, skin tuberculosis, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis); post-vaccination skin reactions, perioral dermatitis, rosacea, trophic ulcers due to chronic venous insufficiency, skin tumors (skin cancer, nevus, atheroma, epithelioma, melanoma, hemangioma, xanthoma, sarcoma).

With caution

Liver failure, children (over 2 years), long-term therapy, especially with the use of occlusive dressings.

Side Effects

Burning, irritation, dryness, hypopigmentation, skin itching, folliculitis, hypertrichosis, dermatitis, acne-like rashes.
When using occlusive dressings – skin maceration, stretch marks, skin atrophy, secondary infection, prickly heat.
With long-term use – skin atrophy, local hirsutism, telangiectasia, purpura, hypopigmentation, hypertrichosis.
When applied to large surfaces – systemic manifestations of side effects of glucocorticosteroids (growth retardation, Itsenko-Cushing syndrome, increased intracranial pressure after treatment, hyperglycemia, glucosuria, hypokalemia, increased blood pressure) or salicylates (pallor, increased fatigue, drowsiness, hyperventilation against the background of tachypnea, nausea, vomiting, hearing loss, confusion consciousness).

Interaction

No interaction of the drug with other drugs has been identified.

Overdose

Acute overdose is unlikely, however, with excessive or prolonged use of the drug, chronic overdose is possible, accompanied by signs of hypercortisolism: hyperglycemia, glycosuria, reversible inhibition of adrenal function, manifestation of Cushing’s syndrome.

Treatment.

Appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual withdrawal of the drug is recommended.

Storage conditions

Keep out of the reach of children at a temperature not exceeding 25 °C.

Shelf life

2 years.
Do not use after expiration date.

Manufacturer

Vertex, Russia