Rebagit, 100 mg 90 pcs.

Pharmacotherapeutic group

Gastroprotective agent

ATCode

A02BX

Pharmacodynamics:

Rebampide increases prostaglandin E2 (PGE2) in gastric mucosa and increases PGE2 and GI2 in the contents of gastric juice.

It has a cytoprotective effect on the gastric mucosa in the damaging effects of ethanol acids and acetylsalicylic acid alkalis.

Promotes activation of enzymes accelerating the biosynthesis of high molecular weight glycoproteins and increases the content of mucus on the surface of the gastric wall.

. Helps improve the blood supply to the gastric mucosa Activates its barrier function Activates alkaline gastric secretion Enhances the proliferation and metabolism of gastric epithelial cells Cleanses the mucosa of hydroxyl radicals and suppresses superoxides produced by polymorphonuclear leukocytes and neutrophils in the presence of Helicobacter pylori protects the gastric mucosa from the damage by bacteria has a gastroprotective effect when the mucosa is exposed to nonsteroidal anti-inflammatory drugs (NSAIDs).

Pharmacokinetics:

Absorption when taken orally is high. After administration at a dose of 100 mg, the peak plasma concentration (Cmaõ) is reached after approximately 2 h and is 340 ng/ml. The elimination half-life (T1/2) is approximately 10 hours. Repeated administration of the drug does not lead to its cumulation in the body. Approximately 10% of the drug is excreted by the kidneys mainly unchanged. When taken in a dose of 600 mg, traces of the hydroxylated metabolite can be excreted.

In in vitro experiments it was shown that from 984% to 986% of the drug is bound to plasma proteins.

Indications

May be used in combination therapy.

Active ingredient

Composition

Composition of the film coating:

Hypromellose – 2.77 mg,

Purified talc – 0.57 mg,

Titanium dioxide – 1.11 mg,

Propylene glycol – 0.55 mg.

How to take, the dosage

Overly, 1 tablet 3 times a day with plenty of fluid. The course of treatment is 2-4 weeks; if necessary, it can be prolonged up to 8 weeks.

The drug has no particular effect when taken for the first time or when it is discontinued.

If you miss a dose, take the next dose of the drug at the prescribed time; you should not take a double dose of the drug.

Interaction

When rebamipide is used as part of traditional therapy regimens in patients with Helicobacter pylori infection, the effectiveness of eradication therapy is significantly increased.

The reactions of interaction with other drugs have not been studied.

Special Instructions

The effect of the drug on the speed of psychomotor reactions and/or the ability to operate vehicles or mechanisms has not been studied. When taking the drug, caution should be exercised when driving a vehicle and other activities requiring increased concentration.

Features

Absorption and distribution

After a dose of 100 mg, Cmax is reached after approximately 2 hours and is 340 ng/ml. Repeated doses of the drug do not result in cumulation in the body.

In in vitro experiments it is shown that 98.4% to 98.6% of the drug is bound to plasma proteins.

Metabolism and excretion

The T1/2 is approximately 1.0 h. Approximately 10% of the drug is excreted by the kidneys, mostly unchanged. When taken at a dose of 600 mg, traces of the hydroxylated metabolite can be excreted.

Contraindications

Side effects

Gastrointestinal tract: constipation flatulence diarrhea nausea vomiting abdominal pain abnormal taste sensation heartburn.

Liver disorders: signs of liver dysfunction increased serum glutamine alanine aminotransferase (ALT) and serum glutamine aspartate aminotransferase (ACT).

Hematopoietic system: leukopenia granulocytopenia.

Allergic reactions: itching skin rash eczematous rash.

Others: menstrual irregularities.

Overdose

Symptoms of rebamipide overdose are not described, no cases of intentional overdose have been reported to date. Nausea, vomiting, abdominal pain, diarrhea or constipation, headache are possible.

Treatment: no specific antidote is known. In case of overdose, gastric lavage and symptomatic therapy should be carried out.

Similarities