Pyridoxine, 50 mg/ml 1 ml 10 pcs

The drug has the effect of replacing the deficiency of vitamin B6.

As we know, vitamin B6 is an essential participant in metabolic processes, normalizes and supports the activity of the nervous system. Phosphorylated form of pyridoxine is a coenzyme of a large number of enzymes that affect the non-oxidative metabolism of amino acids, such as decarboxylation or transamination.

This component is necessary for the metabolism of tryptophan, cysteine, glutamic, methionine and other amino acids. It is also important for the metabolism of histamine and for normalization of lipid metabolism.

The metabolism of the main substance occurs in the liver, resulting in the formation of pharmacologically active metabolites: pyridoxalphosphate and pyridoxamine phosphate. The components are distributed mainly in muscle tissues, as well as in the liver and nervous system. Penetration of the drug into breast milk and through the placenta has been noted. The substance is excreted with the kidneys, part of it is excreted with bile.

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Indications

The drug is used to treat and prevent vitamin B6 deficiency in:

• B6-hypovitaminosis;
• pregnancy toxemia;
• sideroblastic anemia;
• leukopenia;
• diseases of the nervous system;
• sea and air sickness;
• atherosclerosis;
• sugar diabetes;
• dermatitis;
• shingles herpes;
• neurodermatitis
• psoriasis
• exudative diathesis and so on.

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How to take, the dosage

Vitamins in ampoules, as well as Pyridoxine-Vial, the instructions for use indicate use in a daily dosage of 50-150 mg.

Allowed subcutaneous, intramuscular or intravenous administration.

The duration of therapy is determined by the severity and type of the disorder. In the prevention of vitamin B6 deficiency, about 40 mg per day is prescribed.

Interaction

Simultaneous use with isoniazid, cycloserine, penicillamine reduces the effectiveness of pyridoxine. Pharmaceutical incompatibility of vitamin B6 with B1 and B12 has been noted. This drug significantly decreases the antiparkinsonian activity of levodopa.

Combination with hormonal contraceptives can increase the plasma concentration of pyridoxine. Use with phenytoin and phenobarbital may decrease the plasma concentration of these components.

Special Instructions

Caution should be exercised when prescribing this drug in patients with gastric and duodenal ulcer disease and ischemic heart disease.

High doses of pyridoxine can worsen liver function if taken with severe liver damage.

Contraindications

It is not recommended to take the drug if you are sensitive or intolerant to Pyridoxine.

Overdose

In clinical practice, no cases of overdose have been established.

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