Prostudox black currant, 5 g 10 pcs

Prostudox Blackcurrant – replenishing vitamin C deficiency, sympathomimetic, analgesic, antipyretic.

Pharmacodynamics

Combination drug for symptomatic treatment of acute respiratory infections. It provides effective relief of symptoms of colds and flu.

The action of the drug is due to its constituent components.

Paracetamol has antipyretic and analgesic effect, reduces the body temperature and pain syndrome (sore throat, headache).

Phenylephrine is a sympathomimetic, constricts nasal vessels, eliminates swelling of the mucous membrane of the nasal cavity and nasopharynx, as a result of which the runny nose and nasal breathing are reduced.

Ascorbic acid (vitamin C) replenishes the increased need for vitamin C during colds and flu, especially in the initial stages of the disease.

The beginning of action 20-30 minutes after intake, the duration – 4-4.5 hours.

Indications

Symptoms of colds and flu (including fever, headache, chills, nasal congestion, sore throat when swallowing).

Active ingredient

How to take, the dosage

Ingestion. Adults and children over 14 years of age – 1 sachet every 4-6 hours, but not more than 4 sachets in 24 hours.

The drug is not recommended to take more than 5 days without medical advice. If symptoms persist, a physician should be consulted.

Pour the contents of 1 sachet into a glass, fill it with hot water, stir until completely dissolved and add sugar or honey to taste.

Interaction

Stimulants of microsomal oxidation in the liver (including phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which determines the possibility of severe intoxication in small overdoses.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects of the drug.

Paracetamol increases the effects of MAO inhibitors, sedatives and ethanol.

The simultaneous use of Prostudox with ethanol may cause acute pancreatitis.

The concomitant use of Prostudox with antidepressants, antiparkinsonian drugs, antipsychotic drugs, phenothiazine derivatives increases the risk of urinary retention, dry mouth, constipation.

The concomitant use of Prostudox with GCS increases the risk of glaucoma.

Concomitant use with Prostudox decreases the hypotensive effect of guanethidine.

Concomitant use of Prostudox with guanethidine increases the α-adrenergic stimulating effect, with tricyclic antidepressants – the sympathomimetic effect of phenylephrine.

The concomitant use with Prostudox reduces the effectiveness of uricosuric drugs.

In case of delayed gastric emptying (under the influence of propantelin) there may be a delayed onset of action of the drug. When gastric emptying is accelerated (after taking metoclopramide), the drug takes effect more quickly.

Prostudox may increase the effect of indirect anticoagulants.

Special Instructions

Do not concomitantly use other drugs containing paracetamol, as well as other non-narcotic analgesics, NSAIDs (including metamizole, acetylsalicylic acid, ibuprofen), barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.

The simultaneous use of other drugs should be coordinated with the physician.

The drug may interfere with the results of laboratory tests assessing the plasma concentration of glucose and uric acid.

Impact on driving and operating ability

When using Prostudox, the active ingredients of the drug do not cause drowsiness or impair concentration.

Contraindications

With caution:

Side effects

Allergic reactions: sometimes – skin rash, pruritus, urticaria, angioedema.

Hematopoietic system: rarely – thrombocytopenia, leukopenia, agranulocytosis.

The digestive system: rarely – nausea, vomiting, epigastric pain.

Others: rare – increase in intraocular pressure, urinary retention.

Hepatotoxic and nephrotoxic effects may be observed with prolonged use in excess of the recommended dose.

Phenylephrine hydrochloride may cause nausea, headache, increased BP; rarely, a feeling of palpitations. These symptoms go away after discontinuation of the drug.

Overdose

Symptoms: discomfort in epigastric region, nausea, vomiting, pale skin, decreased appetite, hepatonecrosis (severity of necrosis directly depends on the degree of overdose), increased liver transaminases activity, increased prothrombin time (12-48 hours after intake). A full clinical picture of liver damage is seen 1-6 days later. Rarely, liver impairment develops fulminantly and may be complicated by renal failure (renal tubular necrosis).

Treatment: symptomatic, gastric lavage, administration of SH-group donators and precursors of glutathione synthesis – methionine in 8-9 hours after overdose and N-acetylcysteine in 12 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Pregnancy use

The drug is contraindicated in pregnancy and during breast-feeding. Breast-feeding should be stopped during treatment.

Pediatric use

It is contraindicated: Children under 14 years of age.

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