Prostatylene, rectal 30 mg 10 pcs

Pharmacotherapeutic group: chronic prostatitis remedy

ATX code: G04BX

Pharmacological properties

Pharmacodynamics: It has organotropic effect on the prostate. It reduces the degree of edema, leukocytic infiltration of the prostate, which helps to reduce the intensity of the pain syndrome, reduce the volume of the prostate, improve the process of urination by increasing the maximum and average speed of urine flow. Reduces the level of white blood cells in the urine. Stimulates the muscle tone of the bladder, which leads to an increase in the volume of urine during a single urination. Normalizes secretory function of epithelial cells, increases the number of lecithin grains in the acini secretion. It has anti-aggregant effect, reduces thrombosis, thereby preventing the development of venous thrombosis in the prostate.

It improves the quality of life of patients.

Pharmacokinetics: The active ingredient of Prostatylen® is water-soluble peptides which are similar to endogenous human peptides; therefore, no pharmacokinetic studies are possible.

The bioavailability of the drug at the rectal administration is provided by the low molecular weight of the peptide fraction and the presence of dimethyl sulfoxide absorption enhancer, because in the rectal mucosa only passive type of transport of substances with low molecular weight is possible: diffusion through the basal membrane and filtration through the enterocyte cytolemma pores.

Peptides are absorbed by the blood vessels of the rectum and enter the systemic bloodstream directly, without undergoing metabolic changes in the liver, and exert their effect through the system of anastomoses on the pelvic organs, including the prostate, located in anatomic proximity to the injection site.

The peptides are further cleaved by proteases to amino acids, which are then used in the synthesis of tissue-specific proteins. Amino acids that are not used in the process of protein synthesis are deaminated and excreted in the urine.

Indications

Chronic abacterial prostatitis, conditions before and after operations on the prostate, benign prostatic hyperplasia.

Active ingredient

Composition

Composition per 1 suppository:

How to take, the dosage

rectally. The suppository should be moistened with water before use. 1 suppository is inserted deep into the anus after defecation or enema once a day (morning or evening) or 2 times a day (morning and evening). After insertion it is desirable for the patient to stay in bed for 30-40 minutes. The course of treatment is not less than 10 days for chronic prostatitis and not less than 15 days for benign prostatic hyperplasia.

With caution:

It is recommended with caution to use the drug with damage to the mucous membrane of the rectum and the skin of the perianal area.

Interaction

Special Instructions

Contraindications

Hypersensitivity to the components of the drug, children under 18 years.

Side effects

Classification of the frequency of adverse reactions is given according to the recommendations of the World Health Organization (WHO).

Very common – more than 10%; common – 1-10%; infrequent – 0.1-1%; rare – 0.01-0.1%; very rare – less than 0.01%, including individual reports; frequency unknown – cannot be estimated based on available data.

Skin and subcutaneous tissue disorders: frequency unknown – allergic reactions (urticaria). In this case, the drug is discontinued and antihistamines are prescribed.

If you experience or worsen the side effects listed in the instructions, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Pregnancy use

Similarities