Proproten-100, drops 25 ml

The drug modifies the functional activity of S-100 protein that conjugates informational and metabolic processes in the brain. It sensitizes neuronal membrane and modulates synaptic plasticity of neurons. Has a modifying effect on the functional state of brain structures involved in the formation of alcohol dependence: hypothalamus, hippocampus, etc.

In case of alcohol dependence has a normalizing effect on the system of positive emotional reinforcement, which leads to a decrease in the frequency of self-stimulation of the lateral hypothalamus. Reduces patches activity of hippocampal neurons; decreases the number of circulating immunocomplexes in peripheral blood, which correlates with decreased ethanol consumption. It promotes strengthening of the inhibitory effects of GABA in the CNS.

It is experimentally established that the drug restores the neurotransmitter balance and conditioned reflex activity. Increases resistance of the brain to hypoxia and toxic effects.

Indications

Proprothene®-100 is indicated for use in adults.
It is used for alcohol dependence to reduce the craving for alcohol and reduce the likelihood of relapse into alcoholism.

Pharmacological effect

Pharmacotherapeutic group
Drugs used for alcohol dependence.

ATX code
N07BB.

Pharmacological properties

Pharmacodynamics
The drug modifies the functional activity of the S-100 protein, which combines information and metabolic processes in the brain. Sensitizes the neuronal membrane, modulates the synaptic plasticity of neurons. It has a modifying effect on the functional state of brain structures involved in the formation of alcohol dependence: the hypothalamus, hippocampus, etc. In alcohol dependence, it has a normalizing effect on the system of positive emotional reinforcement, which leads to a decrease in the frequency of self-stimulation of the lateral hypothalamus. Reduces burst activity of hippocampal neurons; reduces the number of circulating immune complexes in peripheral blood, which correlates with a decrease in ethanol consumption. Helps enhance the inhibitory effects of GABA in the central nervous system. It has been experimentally established that the drug restores neurotransmitter balance and conditioned reflex activity. Increases the brain’s resistance to hypoxia and toxic influences.

Pharmacokinetics
The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of the active substance of the drug Proproten®-100 in biological fluids, organs and tissues, which makes it technically impossible to study pharmacokinetics.

Special instructions

This medicinal product contains small amounts of ethanol (alcohol), less than 100 mg per 10 drops of the drug.

Impact on the ability to drive vehicles and machinery
During the period of treatment for alcohol dependence, taking into account the specifics of the disease, you should refrain from driving.

Active ingredient

Antibodies

Composition

Composition per 1 g drops for oral administration

Active ingredient:
antibodies to the brain-specific protein S-100, affinity purified – 25,000 EMD*.

Excipients: ethyl alcohol 95%, purified water.
* EMD – units of modifying action.

Pregnancy

The drug Proproten®-100 is contraindicated for use in women during pregnancy and breastfeeding.

Contraindications

Increased individual sensitivity to the components of the drug.
Pregnancy and lactation.
Age up to 18 years.

Side Effects

Individual hypersensitivity reactions to the components of the drug are possible.

Interaction

No cases of incompatibility with other drugs have been identified to date.

Overdose

To date, no cases of overdose have been observed.

Short product description

Proproten-100 is a drug intended for the treatment of alcoholism. The only drug from the group of anti-alcohol drugs that not only reduces and relieves hangover symptoms, but, when taken over the course of a course, eliminates the “craving” for alcohol and prevents the occurrence of new binges. Also used to reduce the amount of alcohol you drink.

Storage conditions

At a temperature not exceeding 25 °C.
After opening, store the bottle at a temperature not exceeding 25 °C for 35 days.
Keep out of the reach of children.
Do not freeze.

Shelf life

2 years. Do not use after expiration date.

Manufacturer

Materia Medica Holding, Russia