Progesterone, 1% 1 ml 10 pcs

Progesterone is a gestagen. Hormone of the corpus luteum. Causes the uterine mucosa to transition from the proliferation phase caused by follicular hormone to the secretory phase and, after fertilization, promotes its transition to the state necessary for the development of the fertilized egg.

It reduces the excitability and contractility of the uterine muscles and fallopian tubes and stimulates the development of mammary gland terminal elements. It has no androgenic activity. Progesterone has a weak effect on protein metabolism, promotes fat deposition and glucose accumulation in the liver, and decreases sodium reabsorption in the renal tubules.

Progesterone has a blocking effect on the secretion of hypothalamic release factors LH and FSH, inhibits the formation of gonadotropic hormones in the pituitary gland and inhibits ovulation.

Pharmacokinetics

After injection, it is absorbed rapidly and almost completely. Metabolized in the liver, most metabolites form conjugates with glucuronic and sulfuric acids.

The T1/2 from plasma is a few minutes. It is excreted with the urine – 50-60% and with the feces – more than 10%. The amount of metabolites that are excreted in the urine varies depending on the phase of the corpus luteum.

Indications

Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, habitual miscarriage. Contraception.

Active ingredient

Composition

Active substance:

Progesterone

How to take, the dosage

The dosing regimen is individual. The dose, frequency and duration of treatment are determined according to the scheme depending on the indication and clinical situation.

Interaction

Limits the intensity of the effect of uterine smooth muscle stimulating drugs, anabolic steroids, gonadotropic hormones of the anterior pituitary lobe.

Limits the lactogenic effect of oxytocin.

It increases the effect of diuretics, antihypertensive drugs, immunosuppressants.

In concomitant use with barbiturates there is a decrease in the effect of progesterone.

Contraindications

Severe hepatic or renal dysfunction, hepatitis, thromboembolic diseases, vaginal bleeding of undetermined genesis, breast carcinoma (except in cases in which progesterone is used as part of combined therapy of this disease).

Side effects

Cardiovascular system: increase in BP.

Metabolism disorders: edema.

In the digestive system: liver dysfunction, jaundice; rarely (with long-term use) – nausea, vomiting.

Endocrine system disorders: rare (in long-term use) – decreased libido, weight gain, pain and tension in the mammary glands, irregular uterine bleeding.

CNS disorders: rarely (with long-term use) – headache, depression.

Similarities