Potassium iodide Reneval, tablets 100 mcg 112 pcs
€4.68 €3.90
Pharmacodynamics
Iodine refers to the vital trace elements necessary for normal functioning of the thyroid gland. When iodide enters the epithelial cells of the thyroid follicle, iodine ions under the influence of the enzyme iodide peroxidase are oxidized to form elemental iodine, which is included in the molecule tyrosine.
At the same time, one part of the thyrosine radicals in thyroglobulin is iodized, resulting in the formation of thyronines, the main ones being thyroxine (T4) and triiodothyronine (T3). Thyronines form a complex with the protein thyroglobulin, which is deposited in the colloid of the thyroid follicle.
Iodine entering the body in physiological amounts, prevents the development of endemic goiter (associated with iodine deficiency in food), normalizes the size of the thyroid gland in infants, children and adolescents, and also affects the ratio of T3/T4, the concentration of thyroid hormone.
Pharmacokinetics
When taken orally it is quickly and completely absorbed in the small intestine and within 2 hours is distributed in the intracellular space.
It accumulates mainly in thyroid gland (iodide concentration more than 0.5 mg/g of tissue) as well as in salivary and mammary glands and gastric mucosa.
It is eliminated mainly by kidneys (trace amounts are determined in urine 10 min after intake, 80% of dose is eliminated within 48 hours, the rest – within 10-20 days), partially – with secretions of salivary, bronchial, sweat and other glands.
Indications
- Prevention of iodine deficiency diseases, including. endemic goiter (especially in pregnant and nursing women);
- prevention of goiter recurrence after goiter surgical removal or after goiter treatment with thyroid hormones;
- treatment of diffuse euthyroid goiter in newborns, children, teenagers and young adult patients.
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Active ingredient
Potassium iodide
Composition
Active ingredient: potassium iodide 131 µg (corresponds to 100 µg of iodine).
Excipients:
magnesium hydroxycarbonate (magnesium carbonate basic) – 0.0175 g
lactose monohydrate (milk sugar) – 0.059869 g
Microcrystalline cellulose – 0,02 g
Magnesium stearate – 0,001 g
Colloidal silica (aerosil) – 0,0005 g
Sodium croscarmellose – 0,001 g.
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How to take, the dosage
When determining the required dose of the drug, regional and individual peculiarities of iodine intake with food should be taken into account. This is especially important when prescribing the drug to newborns and children under 4 years old.
Iodine deficiency disease prevention:
- Infants and children: 50-100 mcg of iodine per day (½-1 tablet of Potassium Iodide 100 mcg);
- Adolescents and adults: 100-200 mcg iodine per day (1 tablet of Potassium Iodide 100 mcg or 1 tablet of Potassium Iodide 200 mcg);
- Pregnancy and lactation: 100-200 mcg iodine per day (1 tablet of Potassium Iodide 100 mcg or 1 tablet of Potassium Iodide 200 mcg).
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Interaction
Concomitant use of antithyroid drugs weakens the effect of potassium iodide (mutually).
Potassium perchlorate and thiocyanate inhibit iodine absorption by the thyroid gland. Thyrotropic hormone improves thyroid uptake of iodine and stimulates thyroid hormone production.
Concomitant use of angiotensin-converting enzyme inhibitors (including captopril, enalapril, lisinopril) increases the risk of hyperkalemia. High doses of iodine in combination with potassium-saving diuretics may lead to hyperkalemia.
Simultaneous therapy with iodine in high doses and lithium preparations contributes to goiter and hypothyroidism.
Potassium iodide reduces thyroid uptake of 131I and 123I.
Special Instructions
Before the start of treatment it is necessary to exclude malignant lesion of the thyroid gland, hyperthyroidism or nodular toxic goiter.
In patients with impaired renal function during therapy with the drug, hyperkalemia may develop (periodic monitoring of blood potassium concentration is necessary).
With regard to the presence of lactose monohydrate in the drug, patients with rare hereditary diseases associated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take the drug.
Impact on ability to drive vehicles, machinery
The drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.
Contraindications
– Hypersensitivity to iodine;
– Severe thyrotoxicosis;
– Latent thyrotoxicosis (when using doses greater than 150 mcg/d);
– Herpetiform dermatitis;
– Toxic adenoma, nodular goiter when used in doses greater than 300 mcg/day (except for preoperative therapy for thyroid blockade);
– Hereditary conditions associated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption.
Potassium iodide should not be taken in hypothyroidism, except in cases when the development of the latter is caused by severe iodine deficiency. Use of the drug should be avoided if therapy with radioactive iodine is present or suspected of thyroid cancer.
With caution
In patients with impaired renal function.
Side effects
When using the drug according to indications in the recommended doses, the occurrence of side effects is unlikely.
Allergic reactions may occur: rare – skin rash, Quincke’s edema.
Overdose
When the drug is administered in a dose of more than 150 mcg per day to patients with foci in the thyroid gland with functional autonomy, iodine-induced hyperthyroidism may develop.
Iodine-induced goiter and hypothyroidism may develop in some cases during therapy with high doses of iodine (over 1 000 mcg per day).
Chronic overdose can lead to the phenomenon of “iodism”: metallic taste in the mouth, swelling and inflammation of mucous membranes (rhinitis, conjunctivitis, gastroenteritis, bronchitis), acne, dermatitis, salivary gland swelling, increased body temperature, irritability.
Pregnancy use
During pregnancy and breastfeeding the need for iodine increases. Potassium iodide is prescribed by indication in cases when dietary iodine intake is less than 150-300 mcg/day. The drug penetrates well through the placenta and may cause the development of hypothyroidism and goiter in the fetus. Iodine is also excreted with breast milk.
Therefore, during pregnancy and breast-feeding the drug should be used only in recommended doses.
Similarities
Iodomarin 200, Iodobalance, Iodomarin 100
Weight | 0.032 kg |
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Shelf life | 3 years. |
Conditions of storage | In the dark place at the temperature not more than 25 °С. Keep out of reach of children. |
Manufacturer | Update PFC AO, Russia |
Medication form | pills |
Brand | Update PFC AO |
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