Portalac, syrup 500 ml

Portalac is a laxative drug. Lactulose under the influence of intestinal microflora breaks down into low molecular weight organic acids in the large intestine.

The formation of acids leads to lowering the pH of the intestinal contents and activation of its peristalsis. Along with this, the volume and softening of stool masses increases.

The drug also reduces the formation of nitrogen-containing toxic substances in the proximal colon and their absorption into the systemic blood flow. In addition, the movement of ammonium ions from the blood to the intestine is enhanced.

The action of the drug occurs 24-48 hours after oral administration.

Indications

Active ingredient

Composition

100 ml of syrup contains:

Active substance:

Lactulose concentrate 66.7 g;

Compound:

Purified water.

How to take, the dosage

Portalac is taken orally, in the morning during or after a meal, once or divided into 2 doses, with water or other liquids. The dose of Portalac is adjusted individually. The starting dose (3 days) is:

Children under 1 year, 5 ml (1 tsp.);

Children 1 to 6 years old, 5-10 ml (1-2 tsp.

Children from 6 to 14 years old take 15 ml (1 tablespoon);

Adults take 15-45 ml.

Interaction

When using therapeutic doses of lactulose no clinically reliable interaction with other medicinal products has been observed.

However, it is not recommended to take Portalac® within 2 hours after taking another drug.

In concomitant administration lactulose may interfere with the action of the drugs, which have an unfavorable environment for release in the large intestine (e.g., drugs containing mesalazine).

Antibiotics (neomycin) and antacids reduce the effect.

Special Instructions

If constipation does not resolve within a few days of taking the drug, and if constipation resumes after discontinuation of the drug, a physician should be consulted.

With regard to the presence of small amounts of sugars in the syrup (15 ml syrup contains up to 1.7 g of galactose and up to 1 g of lactose) caution should be exercised when prescribing with patients with diabetes or lactose intolerance.

Patients with gastrocardia syndrome are treated with caution: treatment starts with low doses and increases them gradually to avoid the occurrence of flatulence.

When treating hepatic encephalopathy, especially in the initial phase of therapy, other laxatives should not be used, because increased bowel emptying may lead to the erroneous conclusion that an adequate dose for encephalopathy therapy has been achieved.

The effect on the ability to drive or perform work requiring increased speed of physical and mental reactions. In the recommended doses, the drug has no effect on the ability to drive vehicles and operate machinery.

Contraindications

Side effects

The side effects are usually mild and reversible and are the result of an overdose.

Spasms, abdominal discomfort or pain, and diarrhea may be resolved by lowering the dose. Meteorism, which appears at the beginning of treatment, usually goes away after 1-2 days.

There have been cases of skin reactions (rash).

In case of prolonged therapy and administration of high doses of lactulose during treatment of hepatic encephalopathy disruptions of water-electrolyte balance may occur, and as a consequence, convulsions, nausea, headache, dizziness, arrhythmia, myalgia, increased fatigue and weakness.

Overdose

Symptoms: Taking too high doses of the drug may cause diarrhea and electrolyte-water balance problems.

Treatment:Cancellation of the drug.

Pregnancy use

Lactulose can be used safely in pregnant and nursing women.

Similarities