Polydex, ear drops 10.5 ml

The combined preparation for topical application in otolaryngology.

The therapeutic effect of Polidex is due to the anti-inflammatory action of dexamethasone and antibacterial action of the antibiotics neomycin and polymyxin B.

When the above antibiotics are combined they broaden the spectrum of antibacterial action against most gram-positive and gram-negative microorganisms causing infectious and inflammatory diseases of the outer and middle ear.

Neomycin is active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae.

Polymyxin B is active against Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa.

The action of these antibiotics is resistant to Streptococcus spp. (including Streptococcus pneumoniae).

Indications

– Outer otitis media without damage to the eardrum;

Infected eczema of the external auditory canal.

Active ingredient

Composition

On 100 ml

The active ingredients:

Neomycin sulfate 1g, which corresponds to 650,000 ME.

Polymyxin B sulfate 1 000 000ME.

Dexamethasone sodium metasulfobenzoate 0.100 g.

Auxiliary substances:

thiomersal,

citric acid,

1N sodium hydroxide solution,

MacroGol 400,

Polysorbate 80,

purified water q.s. up to 100 ml.

How to take, the dosage

Adults: 1-5 drops in each ear 2 times a day for 6-10 days.

Children: 1-2 drops in each ear 2 times a day for 6-10 days. The duration of treatment should not exceed 10 days.

Before using the ear drops it is recommended to warm the bottle by holding it in your hand to avoid discomfort associated with putting cold fluid in the ear.

After putting the product in one ear, you should tilt your head to the opposite side for a few minutes and then put it in the other ear.

Interaction

Incompatible with monomycin, streptomycin, gentamicin, amikacin, netilmicin (increased ototoxicity).

Special Instructions

It should not be administered under pressure.

The simultaneous use of other aminoglycosides is not allowed.

When using neomycin or polymyxin B topically, the development of an allergic reaction may preclude the systemic use of other antibiotics closely related to neomycin and polymyxin B.

In case of allergy to neomycin, cross-allergy to antibiotics – aminoglycosides is possible.

Contraindications

Side effects

Allergic reactions are possible, rarely – skin manifestations.

If the integrity of the eardrum is compromised, there is a risk of toxic effects on the auditory and vestibular system.

Overdose

Due to the low degree of absorption into the systemic bloodstream, overdose is unlikely.

Pregnancy use

In long-term treatment of pregnant women, there is a risk of ototoxic effects on the fetus.

Similarities