Polydex, ear drops 10.5 ml

The combined preparation for topical application in otolaryngology.

The therapeutic effect of Polidex is due to the anti-inflammatory action of dexamethasone and antibacterial action of the antibiotics neomycin and polymyxin B.

When the above antibiotics are combined they broaden the spectrum of antibacterial action against most gram-positive and gram-negative microorganisms causing infectious and inflammatory diseases of the outer and middle ear.

Neomycin is active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae.

Polymyxin B is active against Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa.

The action of these antibiotics is resistant to Streptococcus spp. (including Streptococcus pneumoniae).

Indications

– Otitis externa without damage to the eardrum;

– infected eczema of the external auditory canal.

Pharmacological effect

Combined drug for local use in otolaryngology.

The therapeutic effect of Polydex is due to the anti-inflammatory effect of dexamethasone and the antibacterial effect of the antibiotics neomycin and polymyxin B.

When these antibiotics are combined, the spectrum of antibacterial action on most gram-positive and gram-negative microorganisms that cause infectious and inflammatory diseases of the outer and middle ear is expanded.

Neomycin is active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae.

Polymyxin B is active against gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa.

Streptococcus spp. are resistant to these antibiotics. (including Streptococcus pneumoniae).

Special instructions

Do not administer under pressure.

The simultaneous use of other aminoglycosides is not allowed.

With topical use of neomycin or polymyxin B, the development of an allergic reaction may exclude the possibility of systemic use of other antibiotics similar in structure to neomycin and polymyxin B.

If you are allergic to neomycin, cross-allergy with antibiotics – aminoglycosides is possible.

Active ingredient

Dexamethasone, Neomycin, Polymyxin B

Composition

Per 100 ml

Active ingredients:

Neomycin sulfate 1g, which corresponds to 650,000 IU.

Polymyxin B sulfate 1,000,000ME.

Dexamethasone sodium metasulfobenzoate 0.100 g.

Excipients:

thiomersal,

citric acid,

1N sodium hydroxide solution,

macrogol 400,

polysorbate 80,

purified water q.s. up to 100 ml.

Pregnancy

With long-term treatment of pregnant women, there is a risk of ototoxicity to the fetus.

Contraindications

infectious or traumatic damage to the eardrum;
hypersensitivity to the components of the drug;
suspicion of angle-closure glaucoma;
simultaneous use of MAO inhibitors;
kidney diseases accompanied by albuminuria;
pregnancy;
lactation (breastfeeding);
children up to 2.5 years old.

Side Effects

Allergic reactions are possible, rarely – skin manifestations.

If the integrity of the eardrum is damaged, there is a risk of toxic effects on the auditory and vestibular apparatus.

Interaction

Incompatible with monomycin, streptomycin, gentamicin, amikacin, netilmicin (increased ototoxic effect).

Overdose

Due to the low degree of absorption into the systemic circulation, an overdose is unlikely.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Farmmaster, France