Plendil, 5 mg 30 pcs.

Plendyl – hypotensive, antianginal.

Blocks calcium channels, inhibits influx of calcium ions into the smooth muscle cells of arterial vessels, causes their dilation, reduces PPS, lowers BP, afterload on the heart, increases coronary blood flow, improves myocardial oxygen supply/consumption balance.

Pharmacokinetics

It is completely absorbed from the gastrointestinal tract. Systemic bioavailability is 15%. Binds to plasma proteins by 99%. Plasma concentration is directly proportional to the dose. It is metabolized in the liver. T_1/2 – 24 h. 70% is excreted in the urine (less than 0.5% of the dose unchanged), the rest in the feces.

Indications

Angina, Hypertension (high blood pressure)

Arterial hypertension, angina pectoris.

Active ingredient

Felodipine

Composition

Active ingredient:

felodipine 2.5 mg, 5 mg or 10 mg;

Supplements:

paraffin;

ethanol;

p> hydroxypropyl cellulose;

Hydroxypropyl methyl cellulose;

iron oxide E 172;

anhydrous lactose;

MCC;

Polyethylene glycol 6000;

Polyoxyl 40 hydrogenated castor oil;

propyl gallate;

sodium aluminum silicate;

sodium stearyl fumarate;

titanium dioxide E 171;

purified water

How to take, the dosage

In the mouth, it is recommended to take the tablets in the morning with water. The tablets should not be broken, crumbled, or chewed. The drug can be taken on an empty stomach or after a light breakfast that does not contain a lot of fat or carbohydrates.

There are no data on the use of felodipine in children.

Hypertension. The dose should be adjusted individually. The initial dose is 5 mg once daily. If necessary, the dose may be increased or another antihypertensive drug may be added. The usual maintenance dose of Plendil is 5 to 10 mg once daily. In elderly patients, consideration should be given to starting treatment with a daily dose of 2.5 mg.

Stenocardia. The dose should be adjusted individually. The initial dose is 5 mg once daily; if necessary, the dose is increased to 10 mg once daily.

Interaction

Biotransformation inhibitors (cimetidine) increase plasma concentrations, stimulants (phenytoin, carbamazepine, barbiturates) decrease.

Contraindications

Hypersensitivity, decompensated heart failure, acute myocardial infarction, unstable angina pectoris, pregnancy, children.

Side effects

Often (more than 1%): headache, hot flashes, peripheral edema.

Sometimes (0.1-1%): tachycardia, palpitations, feeling of fatigue, dizziness, paresthesia, nausea, rash, itching.

Rarely (0.01-0.1%): fainting, vomiting, arthralgia, myalgia, sexual disorders, impotence, urticaria.

Very rare (less than 0.01%): gingival hyperplasia, increased liver enzymes, photosensitization, pollakiuria, allergic reactions (fever, angioedema).

Overdose

Symptoms: marked hypotension, bradycardia.

Treatment: transfer patient to supine position; symptomatic therapy – atropine (IV 0.5-1 mg), alpha₁-adrenomimetics, glucose, saline or dextran infusion.

Pregnancy use

It is contraindicated in pregnancy and lactation.

Similarities

Felodipine, Felodip