Platyphylline,extract 2 mg/ml 1 ml 10 pcs

Pharmacokinetics
Passes easily through histohematic barriers (including the blood-brain barrier), cellular and synaptic membranes. When administered in large doses, it accumulates in central nervous system tissues in significant concentrations. It is metabolized in the liver. It undergoes hydrolysis to form platinecin and platinecic acid. It is excreted by the kidneys and through the intestines. It does not cumulate if administered correctly (doses and intervals between injections).

Pharmacodynamics
Mcholine-blocker‑, compared to atropine has less effect on peripheral Mcholine receptors ‑(by action on smooth muscle cells of the gastrointestinal tract and pupil sphincter 5-10 times weaker than atropine). By blocking Mcholinoreceptors‑, it impairs transmission of nerve impulses from postganglionic cholinergic nerves to effector organs and tissues innervated by them (heart, smooth muscle organs, external secretion glands); it also inhibits Ncholinoreceptors ‑(much weaker). Cholin-blocking effect is more pronounced against the background of increased tone of parasympathetic part of autonomic nervous system or action of Mcholinomimetics.‑ It causes tachycardia to a lesser extent than atropine, especially when used in high doses. By reducing the influence of n. vagus it improves cardiac conduction, increases myocardial excitability, increases the blood minute volume.

It has direct myotropic antispasmodic effect, causes dilation of small skin vessels. In high doses it inhibits vasomotor center and blocks sympathetic ganglia, resulting in vasodilatation and decreased blood pressure.

Weaker than atropine it inhibits endocrine glands secretion; causes marked decrease of smooth muscles tone, amplitude and frequency of peristaltic contraction of the stomach, duodenum, small and large intestine, moderate decrease of gallbladder tone (in individuals with biliary hyperkinesia). Causes relaxation of smooth muscles of the uterus, bladder and urinary tract; having antispasmodic effect, eliminates pain syndrome. It relaxes smooth muscles of bronchi caused by increased tone of vagus nerve or cholinomimetics, increases respiratory minute volume, inhibits secretion of bronchial glands, decreases tone of sphincters.

When injected subcutaneously it causes pupil dilation due to relaxation of pupil sphincter. At the same time intraocular pressure increases and accommodation paralysis occurs (relaxation of the ciliary muscles of the ciliary body). Compared to atropine the effect on accommodation is less expressed and shorter.

Excites brain and respiratory center, more so – spinal cord (in high doses convulsions, depression of the central nervous system, vasomotor and respiratory centers are possible).

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

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Pregnancy use