Pirantel, tablets 250 mg 3 pcs

Pirantel is an anthelmintic.

Blocks neuromuscular transmission in susceptible helminthes.

Pharmacodynamics

Acts on helminths in the early phase of development and mature forms, has no effect on larvae in the migration stage. It is active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics

It is practically not absorbed in the gastrointestinal tract. After oral administration at a single dose of 10 mg/kg body weight, Cmax is 0.005-0.13 µg/ml and is reached within 1-3 hours. Partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted in the faeces (50% of the dose taken – unchanged) and in the urine (about 7% – unchanged and as a metabolite).

Indications

Enterobiasis, ascariasis, hookworm disease, necatoriasis.

Pharmacological effect

Pyrantel is an anthelmintic.

Blocks neuromuscular transmission in sensitive helminths.

Pharmacodynamics

It acts on helminths in the early phase of development and on mature forms, does not affect larvae in the migration stage. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics

Practically not absorbed from the gastrointestinal tract. After oral administration in a single dose of 10 mg/kg body weight, Cmax is 0.005–0.13 μg/ml and is achieved within 1–3 hours. Partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted in feces (50% of the dose taken unchanged) and in urine (about 7% unchanged and in the form of a metabolite).

Special instructions

After taking pyrantel, a laxative is not prescribed.

In case of enterobiasis, simultaneous treatment of all persons living together should be carried out. After completion of treatment, it is necessary to conduct a control stool examination for the presence of parasite eggs.

Careful hygiene is necessary (cleaning living quarters and washing clothes to destroy helminth eggs serves as a preventive measure for reinfection).

Active ingredient

Pirantel

Composition

Active ingredient:

pyrantel pamoate equivalent to pyrantel base 250 mg;

Excipients:

corn starch,

gelatin,

purified talc,

magnesium stearate,

sodium carboxymethyl starch.

Pregnancy

Use during pregnancy and breastfeeding is only possible under the strict supervision of a physician.

Side Effects

From the nervous system and sensory organs: rarely – headache, dizziness, drowsiness, insomnia, weakness; in some cases – hearing loss, hallucinations, confusion, paresthesia.

From the gastrointestinal tract: nausea, vomiting, diarrhea, stomach pain; rarely – increased activity of liver transaminases.

Other: skin rash, fever.

Interaction

Should not be administered concomitantly with piperazine (decreased effect).
With simultaneous use, pyrantel increases the concentration of theophylline in plasma.

Storage conditions

The drug should be stored in a dry place, protected from light, at a temperature not exceeding 25°C.

Shelf life

5 years

Manufacturer

Ozon, Russia