Pirantel, suspension 250 mg/5 ml 15 ml

Pirantel – Anthelminthic drug of broad spectrum action. Causes neuromuscular blockade of sensitive helminthes. It is active against Enterobius vermicularis, Ascaris lumbriocoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It acts on both mature and immature individuals of both sexes; it has no effect on larvae in the migratory stage.

Pharmacokinetics

Absorption

Pirantel is poorly absorbed from the gastrointestinal tract after oral administration. After a single dose of 10 mg/kg body weight, the plasma concentration of pyrantel is 0.005-0.13 µg/ml for 1-3 hours.

Distribution

There are no data on the distribution of pyrantel in tissues and body fluids (absorption of the active substance is theoretically minimal), as well as on the possibility of excretion of the active substance with the breast milk.

Metabolism and excretion

Pirantel absorbed into the systemic bloodstream is partially metabolized in the liver to N-methyl-1,3-propanediamine. 93% of the administered dose is excreted unchanged in the feces, about 7% in the urine unchanged or as a metabolite.

Indications

Active ingredient

Composition

Active substance:

Pyrantel 250 mg;

Associates:

sorbic acid,

sucrose,

xanthan gum,

methylparahydroxybenzoate,

propylparahydroxybenzoate,

sorbitol 70% solution,

polysorbate 80,

Chocolate flavoring S 2761 (composition: propylene glycol, water, caramel dye, natural, identical to natural and artificial flavors), “ice cream” flavoring (composition: propylene glycol, water, caramel dye, natural, identical to natural and artificial flavors),

water purified.

How to take, the dosage

Internal administration. The dose and frequency of administration are determined individually depending on indications, age and body weight of the patient.

In case of ascariasis and enterobiasis the dose is prescribed once at the rate of 10 mg/kg: adults and children over 12 – 750 mg (if body weight over 75 kg – 1 g); children from 6 months to 2 years – 125 mg, 2-6 years – 250 mg, 6-12 years – 500 mg. In order to avoid self-infection, it is recommended to repeat the course in 3 weeks after the first intake.

In case of ankylostomiasis – 10 mg/kg in 1 dose for 3 days.

In Necatorosis (severe forms) – 20 mg/kg/day for 2 days.

In isolated ascariasis – 5 mg/kg once.

The tablets should be chewed before swallowing.

Interaction

When concomitant use with piperazine the effect of Pirantel is weakened.

Pharmacokinetic interaction

Pirantel may increase the blood plasma concentration of theophylline when used concomitantly.

Special Instructions

In case of enterobiasis, concomitant treatment of co-infected persons should be carried out. After completion of treatment, a control stool examination for worm eggs should be carried out.

Contraindications

With caution. Pregnancy, hepatic insufficiency.

Side effects

Nervous system and sensory organs: rarely – headache, dizziness, drowsiness, insomnia, weakness; in some cases – hearing impairment, hallucinations, confusion, paresthesias.

Gastrointestinal system disorders: nausea, vomiting, diarrhea, stomach pain; rarely – increased liver transaminase activity.

Others: skin rash and fever.

Overdose

No cases of overdose have been described.

In case of overdose, symptomatic treatment should be taken.