Phlebopress, capsules 300 mg 30 pcs

A semi-synthetic bioflavonoid (rutin derivative) of benzopyran class, has P-vitamin activity, has venotonic, angioprotective, anti-inflammatory and anti-edema effect, reduces capillary permeability and fragility.

His pharmacodynamic properties are associated with the participation of bioflavonoids of troxerutin in redox processes and hyaluronidase inhibition. Inhibiting hyaluronidase, troxerutin stabilizes hyaluronic acid of cell membranes and reduces their permeability.

It has antioxidant activity, as a result of which it prevents oxidation of ascorbic acid, adrenaline and lipids. In addition, it reduces capillary permeability and fragility and prevents damage to the basal membrane of endothelial cells when various factors are acting on it.

Troxerutin increases the density of the vascular wall, reduces the exudation of the liquid part of the plasma and the diapedesis of the blood cells. Reduces exudative inflammation in the vascular wall by reducing platelet adhesion to its surface. Inhibits aggregation and increases the degree of red blood cell deformation.

The use of troxerutin is possible both in the initial and in the late stages of treatment of chronic venous insufficiency, it is possible to use as one of the components of complex treatment. Troxerutin reduces swelling and heaviness in the legs, decreases the intensity of pain and cramps and improves tissue trophism.

Troxerutin relieves symptoms associated with hemorrhoids (pain, exudation, itching, bleeding).

With its influence on the permeability and resistance of capillary walls, troxerutin helps to slow down the progression of diabetic retinopathy. The effect of troxerutin on the rheological properties of the blood helps to prevent the development of retinal vascular microthrombosis.

Pharmacokinetics

Troxerutin is quickly absorbed when the drug is taken orally. Maximum plasma concentration of troxerutin (Cmax) is established on average 1.75 ± 0.46 hours after oral administration. Absorption is approximately 10-15%. Bioavailability of the drug increases with increasing dose.

The elimination half-life (T1/2) is 6.77 ± 2.37 hours. The therapeutic concentration of the drug in plasma is maintained for 8 hours. In 30 hours after troxerutin administration a second maximum of the drug concentration in plasma is observed due to enterohepatic recirculation.

Partially metabolized in the liver to form glucuronide and trihydroethylquercitin. It is excreted mainly through the intestine (up to 65-70%), a smaller part of the drug (up to 25%) is excreted unchanged by the kidneys.

Indications

The drug Phlebopress® capsules 300 mg is used in the complex therapy of the above diseases:

– chronic venous insufficiency;

– trophic disorders in chronic venous insufficiency and trophic ulcers;

– varicose veins;

– superficial thrombophlebitis, periphlebitis;

– postthrombotic syndrome;

– post-traumatic edema and soft tissue hematomas;

– as adjunctive treatment after sclerotherapy and/or removal of varicose veins of the lower extremities;

– hemorrhoids (to relieve symptoms);

– diabetic angiopathy, retinopathy.

Active ingredient

Composition

The active ingredient:

troxerutin – 300.00 mg.

Excipients:

Lactose monohydrate (milk sugar) – 39.50 mg;

sodium carboxymethyl starch – 7.00 mg;

Magnesium stearate – 3.50 mg.

How to take, the dosage

Ingestion. Capsules should be swallowed whole with meals, drinking enough water.

In the initial phase of treatment, 1 capsule (300 mg) 3 times a day is prescribed. The effect usually develops within 2 weeks. After that, treatment is continued in the same dose, or it is reduced to an average therapeutic dose of 1 capsule 2 times a day (600 mg), or it is stopped (in which case the effect is maintained for at least 4 weeks).

If necessary, the dose can be increased after consultation with the doctor. The course of treatment averages 3-4 weeks.

For maintenance therapy, 1 capsule (300 mg) per day for 3 to 4 weeks is sufficient.

In diabetic retinopathy patients take 2 capsules (single dose of 600 mg) 3 times daily (daily dose 1.8 g).

The average duration of therapy is 3 to 4 weeks.

The need for longer treatment is determined after consultation with a physician and on an individual basis.

Interaction

Special Instructions

There is insufficient experience with Flebopress® in children under 18 years of age. In the treatment of superficial thrombophlebitis or deep vein thrombosis the use of the drug does not exclude the need to prescribe anti-inflammatory and antithrombotic therapy.

Flebopress® is ineffective in edema due to concomitant liver, kidney and heart disease.

The maximum periods and recommended doses should not be exceeded when using the drug alone.

If symptoms do not decrease or get worse while using the drug, you should see a physician immediately.

The effect of the drug on driving and operating machinery

Prevention with Flebopress® has no effect on motor and mental reactions and does not hinder driving and operating of other complex machines.

Contraindications

– hypersensitivity to troxerutin and other components of the drug;

– gastric ulcer, duodenal ulcer, chronic gastritis in the acute phase;

– Lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;

– pregnancy (1st trimester);

– breastfeeding period;

– children under 18 years of age (experience of use is limited).

With caution:

– Chronic renal failure (with prolonged use).

Side effects

Troxerutin is very well tolerated, in rare cases there are mild adverse reactions.

Immune system disorders: hypersensitivity reactions.

Nervous system disorders: headache.

vascular disorders: blood rushes to the face.

Gastrointestinal tract disorders: nausea, vomiting, stomach pain, flatulence, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract. Skin and subcutaneous tissue disorders: erythema, skin itching, skin rash.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor!

Overdose

Symptoms. Troxerutin has very low toxicity. In overdose the following symptoms may occur: agitation, nausea, headache, “rushes” of blood to the face.

Treatment. It is necessary to flush the stomach, take activated charcoal (within an hour after ingestion). If necessary, symptomatic and supportive treatment is carried out.

In case of overdose seek medical attention immediately.

Similarities