Phlebodia 600,600 mg 60 pcs

ATC code:
С05СА03

PHARMACOLOGICAL PROPERTIES
Pharmacodynamics

Venotoninizing and angioprotective agent with vasoconstrictor effect, increasing capillary resistance and reducing their permeability.

It has anti-edematous, fibrinolytic and anti-inflammatory effects.

Venotonic and angioprotective effects have been demonstrated in clinical trials.

Venotonizing effects

Increased vasoconstrictor effects of adrenaline, noradrenaline and serotonin on superficial arm veins or isolated saphenous vein.
Increase in venous tone as assessed by venous capacity measurement with plethysmography; reduction of blood stasis in the veins.
Venotonic effect is dose-dependent.
Decrease in mean venous pressure (in both superficial system and deep veins) demonstrated by dopplerography in a double-blind placebo-controlled clinical trial.
Increase in systolic and diastolic blood pressure in orthostatic hypotension in the postoperative period.
Activity after safenectomy.
Angioprotective effect

Dose-dependent increase in capillary resistance.
Pharmacokinetics

Absorption

After oral administration of Phlebodia 600, diosmin is metabolized by intestinal bacteria to diosmetin. Diosmethine is absorbed and found in the bloodstream as conjugates (glucuronides and sulfates). The main metabolite of diosmin is diosmetin-3-O-glucuronide.

Peak plasma concentrations are reached between 12 and 15 hours after administration of Phlebodia 600.

Distribution

An animal pharmacokinetic study of carbon-14-labeled diosmin showed preferential distribution of radioactivity in the vena cava and saphenous veins.

Excretion

In animals, 79% is excreted with urine, 11% with feces, and 2.4% with bile, confirming intestinal-hepatic recirculation.

In humans, diosmetin-3-O-glucuronide is found in urine.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Pregnancy use

Similarities