Phenystil, drops 1 mg/ml 20 ml

Pharmacological action – antihistamine, anti-allergic, antipruritic.

Pharmacodynamics

Antihistamine, anti-allergic and antipruritic agent. Blocker of H1-histamine receptors, is a competitive histamine antagonist.

The drug reduces increased capillary permeability associated with allergic reactions. It also has anti-bradykinin and weak m-cholin-blocking effects. A slight sedative effect may be noted when taking the drug in the daytime.

Pharmacokinetics

It is quickly and completely absorbed when taken orally.

The bioavailability is about 70%.

The Tmax of dimethindene in plasma after oral administration of drops is 2 hours. Binding with plasma proteins is 90%. It penetrates into the tissues well. Metabolized in the liver through hydroxylation and methoxylation. T1/2 is 6 hours. It is excreted in the bile and urine (90% – as metabolite and 10% – unchanged).

Indications

– Allergic diseases (urticaria, hay fever, year-round allergic rhinitis, angioedema, food and drug allergies);

– skin itching of different origin (eczema, pruritic dermatosis, including atopic dermatitis.

– prevention of allergic reactions during hypersensitization therapy.

Active ingredient

Composition

How to take, the dosage

Interaction

Accelerates the effect of anxiolytics, sleeping pills.

In case of concomitant use of ethanol – slower psychomotor reactions.

Tricyclic antidepressants and m-cholinoblockers increase the risk of increased IOP.

MAO inhibitors increase anticholinergic and CNS depressant effects.

Special Instructions

Phenystil® Drops should not be exposed to heat; if prescribed for infants, they should be added to a bottle of warm baby food immediately before feeding. If the baby is already being spoon-fed, the drops can be given undiluted. The drops have a pleasant taste. If used in children under 1 year of age, consult a doctor and use only if indicated to use H1-histamine receptor blockers. Do not exceed the recommended dose. Ineffective in itching associated with cholestasis.

Impact on the ability to drive and operate machinery. Similar to other antihistamines, Phenystil® may impair attention, so it should be taken with caution when driving, operating machinery, or other activities where increased attention is required.

Synopsis

Contraindications

– hypersensitivity to dimethindene and other components of the drug;

– closed-angle glaucoma;

– bronchial asthma;

– prostatic hyperplasia;

– pregnancy (1st trimester);

– lactation;

– children (under 1 month).

With caution: chronic obstructive pulmonary diseases; children under 1 year of age, because the sedative effect may be accompanied by episodes of nocturnal apnea.

Side effects

Overdose

Symptoms: CNS depression and somnolence (mainly in adults), CNS stimulation and m-cholinoblocking effects (especially in children), including agitation, ataxia, tachycardia, hallucinations, tonic-clonic seizures, mydriasis, dry mouth, flushes to the face, urinary retention and fever; BP decrease, collapse.

Treatment: administration of activated charcoal, saline laxatives, drugs to support cardiac and respiratory system activity (analeptic drugs should not be used).

Pregnancy use

Similarities