Phenotropil, tablets 100 mg 30 pcs

Pharmacotherapeutic group: nootropic

ATX code: N06BX

Pharmacodynamics

Fenotropil is a nootropic medicine with evident anti amnesic effect, direct activation of cerebral integrative activity, contributes to memory consolidation, improves concentration and mental performance, facilitates learning process, increases information transfer speed between cerebral hemispheres, increases brain tissue resistance to hypoxia and toxic effects, has anticonvulsant and anxiolytic effects, regulates activation and inhibition processes.

Phenotropil has a positive effect on metabolic processes and blood circulation in the brain, stimulates redox processes, increases the body’s energy potential by utilization of glucose, improves regional blood flow in ischemic brain areas. It increases norepinephrine, dopamine and serotonin content in the brain, does not affect the level of GABA content, binds neither to GABA nor GABA receptors and has no significant effect on spontaneous bioelectrical activity of the brain.

Phenotropil has no effect on respiration and cardiovascular system, shows slight diuretic effect, has anorexigenic activity when used regularly.

The stimulating effect of FENOTROPIL is seen in its ability to produce a moderate effect on motor reactions, increased physical performance, pronounced antagonism to the cataleptic action of neuroleptics and weakening of the pronounced hypnotic effect of ethanol and hexenal.

The psychostimulant effect of PENOTROPIL predominates in the ideational sphere.

Moderate psychostimulant effect of the drug is combined with anxiolytic activity, improves mood, has some analgesic effect, increasing the threshold of pain sensitivity.

The adaptogenic effect of FENOTROPIL is shown in increasing the resistance of the organism to stress under conditions of excessive mental and physical strain, fatigue, hypokinesia and immobilization, low temperatures.

Phenotropil causes improvement of vision, which is manifested by increase of visual acuity, brightness and visual fields.

Phenotropil improves blood flow to the lower extremities.

Phenotropil stimulates the production of antibodies in response to antigen introduction, indicating that it has immunostimulatory properties, but at the same time it does not promote immediate hypersensitivity and does not change the allergic skin inflammatory response following the introduction of a foreign protein.

Phenotropyl does not cause drug dependence, tolerance or withdrawal symptoms.

The action of FENOTROPIL starts with a single dose, which is important when using the drug in extreme conditions.

PHENOTROPIL has no teratogenic, mutagenic, carcinogenic and embryotoxic properties. Toxicity is low, the lethal dose in an acute experiment is 800 mg/kg.

Pharmacokinetics

Phenotropyl is rapidly absorbed, penetrates various organs and tissues, easily passes through the blood-brain barrier. Absolute bioavailability of the drug when administered orally is 100%. Maximum concentration in blood is reached after 1 hour, half-life is 3-5 hours. Fenotropil is not metabolized in the body and is excreted unchanged. About 40% of the drug is excreted with urine and 60% of the drug is excreted with bile and sweat.

Indications

Diseases of the central nervous system of various origins, especially those associated with vascular diseases and metabolic disorders in the brain, intoxication (in particular in post-traumatic conditions and phenomena of chronic cerebrovascular insufficiency), accompanied by a deterioration in intellectual and mnestic functions, and a decrease in motor activity.

Neurotic conditions manifested by lethargy, increased exhaustion, decreased psychomotor activity, impaired attention, and memory impairment.

Disturbances in learning processes.

Mild to moderate depression.

Psychoorganic syndromes manifested by intellectual-mnestic disorders and apathetic-abulic phenomena, as well as flaccid apathetic states in schizophrenia.

Convulsive states.

Obesity (alimentary-constitutional origin).

Prevention of hypoxia, increasing resistance to stress, correction of the functional state of the body in extreme conditions of professional activity in order to prevent the development of fatigue and increase mental and physical performance, correction of circadian biorhythm, inversion of the sleep-wake cycle;

Chronic alcoholism (in order to reduce the phenomena of asthenia, depression, intellectual and mental disorders).

Pharmacological effect

Pharmacotherapeutic group: nootropic agent

ATX code: N06BX

Pharmacodynamics

PHENOTROPIL is a nootropic drug that has a pronounced anti-amnestic effect, has a direct activating effect on the integrative activity of the brain, promotes memory consolidation, improves concentration and mental activity, facilitates the learning process, increases the speed of information transfer between the hemispheres of the brain, increases the resistance of brain tissue to hypoxia and toxic effects, has an anticonvulsant effect and anxiolytic activity, regulates the processes of activation and inhibition of the central nervous system, improves mood.

FENOTROPIL has a positive effect on metabolic processes and blood circulation in the brain, stimulates redox processes, increases the body’s energy potential through the utilization of glucose, and improves regional blood flow in ischemic areas of the brain. Increases the content of norepinephrine, dopamine and serotonin in the brain, does not affect the level of GABA content, does not bind to either GABAA or GABAB receptors, and does not have a noticeable effect on the spontaneous bioelectrical activity of the brain.

FENOTROPIL has no effect on respiration and the cardiovascular system, exhibits an unpronounced diuretic effect, and has anorexigenic activity when used in a course.

The stimulating effect of FENOTROPIL is manifested in its ability to have a moderately pronounced effect in relation to motor reactions, in increasing physical performance, in pronounced antagonism to the cataleptic effect of neuroleptics, as well as in weakening the severity of the hypnotic effect of ethanol and hexenal.

The psychostimulating effect of FENOTROPIL prevails in the ideational sphere.

The moderate psychostimulating effect of the drug is combined with anxiolytic activity, improves mood, and has some analgesic effect, increasing the threshold of pain sensitivity.

The adaptogenic effect of PHENOTROPIL is manifested in increasing the body’s resistance to stress under conditions of excessive mental and physical stress, fatigue, hypokinesia and immobilization, and low temperatures.

While taking PHENOTROPIL, an improvement in vision was noted, which manifests itself in an increase in acuity, brightness and visual fields.

FENOTROPIL improves blood supply to the lower extremities.

FENOTROPIL stimulates the production of antibodies in response to the introduction of an antigen, which indicates its immunostimulating properties, but at the same time it does not contribute to the development of immediate hypersensitivity and does not change the allergic inflammatory reaction of the skin caused by the introduction of a foreign protein.

With a course of use of PHENOTROPIL, drug dependence, tolerance, and “withdrawal syndrome” do not develop.

The effect of FENOTROPIL is manifested with a single dose, which is important when using the drug in extreme conditions.

FENOTROPIL does not have teratogenic, mutagenic, carcinogenic or embryotoxic properties. Toxicity is low, the lethal dose in an acute experiment is 800 mg/kg.

Pharmacokinetics

FENOTROPIL is quickly absorbed, penetrates various organs and tissues, and easily passes through the blood-brain barrier. The absolute bioavailability of the drug when taken orally is 100%. The maximum concentration in the blood is reached after 1 hour, the half-life is 3-5 hours. FENOTROPIL is not metabolized in the body and is excreted unchanged from the body. Approximately 40% of the drug is excreted in the urine and 60% of the drug is excreted in bile and sweat.

Special instructions

With excessive psycho-emotional exhaustion against the background of chronic stress and fatigue, chronic insomnia, a single dose of PHENOTROPIL on the first day can cause a sharp need for sleep. Such patients on an outpatient basis should be advised to start taking the course of the drug on non-working days.

Active ingredient

Phenylpiracetam

Composition

One tablet contains:

active ingredient:

phenylpiracetam – 50.00 mg or 100.00 mg;

excipients:

povidone K-17, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate.

Pregnancy

FENOTROPIL should not be prescribed during pregnancy and breastfeeding due to the lack of clinical trial data.

Use in pediatrics

Prescribing FENOTROPIL to children is not recommended due to the lack of data on the use of the drug in children.

Contraindications

Individual intolerance.

With caution

FENOTROPIL is used with caution in patients with severe organic damage to the liver and kidneys, severe arterial hypertension, in patients with atherosclerosis, as well as in patients who have previously suffered panic attacks, acute psychotic states occurring with psychomotor agitation – due to the possibility of exacerbation of anxiety, panic, hallucinations and delirium, as well as in patients prone to allergic reactions to nootropic drugs of the pyrrolidone group.

Side Effects

Insomnia (if the drug is taken after 15:00). In some patients, in the first 1-3 days of taking the drug, psychomotor agitation, skin hyperemia, a feeling of warmth, and increased blood pressure may occur.

Interaction

FENOTROPIL can enhance the effect of drugs that stimulate the central nervous system, antidepressants and nootropic drugs.

Overdose

There were no cases of overdose.

Treatment: symptomatic therapy.

Storage conditions

In a place protected from light at a temperature not exceeding 30 ° C.
Keep out of the reach of children.

Shelf life

3 years.
Do not use after expiration date.

Manufacturer

Valenta Pharm JSC, Russia