Pentoxifylline, 20 mg/ml 5 ml 10 pcs

Pentoxifylline is a drug that improves microcirculation. Angioprotector.

It improves microcirculation and blood rheology, has a vasodilator effect, blocks phosphodiesterase and promotes u-AMP accumulation in cells. Increases the elasticity of the erythrocyte membrane, reduces their adhesion, reduces platelet aggregation and blood viscosity. It blocks adenosine receptors.

Pharmacokinetics

Metabolized by the liver. Several active metabolites are formed during metabolism.

The drug is excreted mainly through the kidneys as metabolites. Less than 4% of the administered dose is excreted in the feces.

In patients with impaired hepatic function the bioavailability of the drug is increased and its T1/2 is prolonged.

Indications

Active ingredient

How to take, the dosage

Interaction

Pentoxifylline increases the effect of heparin, fibrinolytic drugs, theophylline, antihypertensive and hypoglycemic agents (both insulin and oral hypoglycemic agents).

Pentoxifylline may increase the effect of anticoagulant drugs (indirect and direct anticoagulants, thrombolytics), antibiotics (including cephalosporins – cefamandol, cefoperazone, cefotetan), valproic acid.

Cimetidine increases the plasma concentration of pentoxifylline (risk of side effects).

The co-administration with other xanthines may lead to excessive patient jitters.

Contraindications

Side effects

Digestive system: dry mouth, decreased appetite, intestinal atony, exacerbation of cholecystitis, cholestatic hepatitis.

Sensory system disorders: visual impairment, scotoma.

Cardiovascular system: tachycardia, arrhythmia, cardialgia, progression of angina, decreased blood pressure.

Hematopoietic and hemostatic system disorders: thrombocytopenia, leukopenia, pancytopenia, hypofibrinogenemia; bleeding from blood vessels of the skin, mucous membranes, stomach, intestines.

Allergic reactions: itching, skin hyperemia, urticaria, angioedema, anaphylactic shock.

Laboratory measures: increase of “liver” transaminases activity (ALT, ACT, LDH) and alkaline phosphatase.

Overdose

Symptoms: nausea, dizziness, cyanosis, tachycardia, marked decrease in blood pressure, redness of the skin, increased body temperature (chills), agitation, areflexia, tonic-clonic convulsions, “coffee grounds” vomiting, arrhythmia loss of consciousness.

Treatment: symptomatic. Particular attention should be aimed at maintaining blood pressure and respiratory function. Seizures are relieved by administration of diazepam. Urgent measures in case of severe anaphylactic reactions (shock):

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