Paracetamol, tablets 500 mg, 20 pcs.

Paracetamol is an analgesic and antipyretic. It blocks the synthesis of prostaglandins in the central nervous system by inhibiting cyclooxygenase 1 and cyclooxygenase 2, affecting the centers of pain and thermoregulation. It has no anti-inflammatory effect. Due to the absence of influence on the synthesis of prostaglandins in peripheral tissues, it has no negative effect on water-salt metabolism (retention of sodium and water) and gastrointestinal mucosa.

Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. It binds to plasma proteins by 15%. Paracetamol penetrates the blood-brain barrier. Less than 1% of the dose of paracetamol taken by a nursing mother penetrates into breast milk. The therapeutically effective plasma concentration of paracetamol is achieved when administered at a dose of 10-15 mg/kg body weight. The elimination half-life is 1-4 hours. Paracetamol is metabolized in the liver and excreted in the urine, mainly as glucuronides and sulfated conjugates, less than 5% is excreted unchanged in the urine.

Indications

Myalgia (muscle pain), Toothache, Joint Pain (Arthralgia), Headache, SARS, Flu, Increased Body Temperature

To quickly relieve headache, including migraine pain, toothache, neuralgia, muscle and rheumatic pain, as well as algodysmenorrhea, pain from injuries, burns; to reduce fever with colds and the flu.

Active ingredient

Paracetamol

Composition

Affective ingredient: paracetamol 500 mg,

Auxiliary substances: gelatin, potato starch, stearic acid, milk sugar (lactose).

How to take, the dosage

For adults the single dose of paracetamol is 0.35-0.5 g 3-4 times a day, the maximum single dose for adults is 1.5 g, the maximum daily dose is 3-4 g. The drug should be taken after the meal with plenty of water.

For children from 9 to 12 years old the maximum daily dose is 2 g.

For children from 3 to 6 years old the maximum daily dose is 1-2 g of paracetamol at the rate of 60 mg per 1 kg of body weight in 3-4 doses.

Interaction

The drug when taken for a long time increases the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Inducers of microsomal oxidation enzymes in the liver (barbiturates, diphenine, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effects in overdose.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

Ethanol promotes acute pancreatitis.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects. Concomitant use with other non-steroidal anti-inflammatory drugs increases nephrotoxic effects.

The simultaneous long-term administration of high-dose paracetamol and salicylates increases the risk of renal and bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50% – the risk of hepatotoxicity.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug. Metoclopramide and domperidone increase, and cholestyramine reduces the absorption rate of paracetamol. The drug may decrease the activity of uricosuric drugs.

Special Instructions

Consult your doctor before taking this medicine:

• You have severe liver or kidney disease;
• You are taking anti-nausea and vomiting medications (metoclopramide, domperidone) and blood cholesterol-lowering drugs (cholestyramine);
• You are taking anticoagulants and you need pain medications daily for a long time. Paracetamol may only be taken rarely;

to avoid toxic liver damage, do not take paracetamol with alcoholic drinks, or with people who have a tendency to drink alcohol spirits chronically.

Peripheral blood count and liver function should be monitored during long-term treatment.

Contraindications

• high sensitivity to paracetamol or any other ingredient;
• severe hepatic or renal impairment;
• children (under 3 years)

With caution: Use with caution in benign hyperbilirubinemia (incl.

With caution: use with caution in benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholic liver damage, glucose-6-phosphate dehydrogenase deficiency, alcoholism, pregnancy, lactation, elderly people. The drug should not be taken simultaneously with other paracetamol-containing drugs.

Side effects

In the recommended doses, the drug is usually well tolerated. Paracetamol rarely causes side effects. Allergic reactions (skin rash, pruritus, urticaria, Quincke’s edema), erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), dizziness, nausea, epigastric pain; anemia, thrombocytopenia, agranulocytosis; insomnia may sometimes be observed. If prolonged use in high doses – the probability of liver and kidney function disorders and hematopoietic system disorders increases.

In the digestive system: nausea, epigastric pain, increased activity of liver enzymes, hepatonecrosis. Endocrine system disorders: hypoglycemia. In case of unusual symptoms consult a physician.

Overdose

Signs of paracetamol overdose are nausea, vomiting, stomach pain, pale skin, anorexia. In a day or two, signs of liver damage are determined. In severe cases liver failure and coma develop. N-acetylcysteine is a specific antidote for paracetamol poisoning.

Symptoms: pale skin, anorexia, nausea, vomiting; hepatonecrosis (severity of necrosis depends directly on the degree of overdose). If overdose is suspected, seek medical attention immediately. Toxic effects of the drug in adults may be observed after taking over 10-15 g of paracetamol: increase of “hepatic” transaminases activity, increase of prothrombin time (12-48 hours after intake); clinical picture of liver damage becomes apparent after 1-6 days. Rarely, liver dysfunction develops fulminantly and may be complicated by renal failure (tubular necrosis).

Treatment: the victim should undergo gastric lavage during the first 4 hours of poisoning, take adsorbents (activated charcoal) and consult a physician, administration of SH-group donators and precursors of glutathione synthesis – methionine in 8-9 hours after overdose and N-acetylcysteine – in 12 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Pregnancy use

Pregnancy, breastfeeding, and children under 3 months of age use with caution.

Similarities

Efferalgan, Cefekon D, Paracetamol, Paracetamol for children, Paracetamol Renewal, Paracetamol, tablets 500 mg 10 pcs