Panzinorm 10000,21 pcs.

Panzinorm 10000 is a combined drug, the effect of which is due to the components included in its composition. The drug compensates for the insufficiency of the external secretory function of the pancreas.

The high lipase activity plays an important role in the treatment of maldigestion due to pancreatic enzyme insufficiency.

Lipase breaks down fats by hydrolysis into fatty acids and glycerol, thus promoting their absorption and the absorption of fat-soluble vitamins.

Amylase breaks down carbohydrates into dextrins and sugars, while protease breaks down proteins.

The drug has a protective coating so that the active enzymes are released in the small intestine, where the pancreatic enzymes act.

The enzymes in pancreatin include lipase, amylase and protease, which facilitate the digestion of fats, carbohydrates and proteins and thus contribute to their more complete absorption in the small intestine. It alleviates symptoms resulting from digestive disorders (a feeling of heaviness and overflow of the stomach, flatulence, shortness of breath, shortness of breath due to accumulation of gas in the intestines, and diarrhea).

It improves digestion in children; stimulates the release of their own pancreatic, stomach and small intestinal enzymes and bile.

Pharmacokinetics

Panzinorm 10000 comes in the form of a capsule, inside which there are pellets covered by a film coating. The film coating of the pellets protects the active enzymes from the acidic environment of the stomach, allowing the enzymes to be released in the small intestine. Most of the enzymes are inactivated, through autolysis and proteolysis. A small portion of the digestive enzymes is excreted through the intestine.

Indications

Active ingredient

Composition

Active ingredient:

Pancreatin powder (pork, in pellet form) 96.6-123.9 mg;

Associates:

gelatin;

Titanium dioxide (E171);

Sodium lauryl sulfate.

How to take, the dosage

To be taken orally with a meal or snack. Capsules should be taken whole, without chewing with enough liquid.

The dose and duration of therapy is determined individually depending on age, degree of pancreatic function deficiency and diet. For adults, Panzinorm 10,000 is recommended to be taken at the beginning of treatment in the minimum dosage of 1-2 caps. 3 times a day, at each main meal (breakfast, lunch, dinner) and 1 caps. at each snack. If necessary, the single dose is gradually increased. The effective daily dose is 4 to 15 drops of the drug Panzinorm 10 000.

The lowest effective dose should be taken, especially in patients with cystic fibrosis.

In children, the drug is used as prescribed by the physician. For children over 3 years of age, take 1-2 capsules of Panzinorm 10,000 with a meal or snack.

The duration of treatment may vary from a single dose or a few days (if digestive disorders due to errors in diet) to several months or years (if permanent replacement therapy is necessary).

Interaction

In long-term use of pancreatin at high doses, the absorption of iron preparations may be reduced (clinically insignificant) and folic acid. Periodic monitoring of folate levels and/or administration of folic acid is recommended.

In concomitant use with cimetidine, bicarbonates, periodic monitoring of folate levels and/or administration of folic acid is also recommended.

Pancreatin may decrease the effectiveness of acarbose and miglitol. The acid-resistant coating of Panzinorm 10000 pellets dissolves in the duodenum. At low pH values in the duodenum, pancreatin is not released. Concomitant use of H2-histamine receptor blockers (cimetidine), hydrocarbonates, proton pump inhibitors may lead to increased effectiveness of pancreatin, which allows reducing the dose of Panzinorm 10000.

Special Instructions

Panzinorm 10,000 should be taken without chewing, with plenty of fluid.

In cystic fibrosis, if the necessary dose of pancreatin is exceeded (more than 10,000 UF of lipase per 1 kg body weight), strictures (fibrous colonopathy) may develop in the ileocecal and ascending colon. Therefore, in cystic fibrosis the dose should be adequate to the amount of enzymes needed for fat absorption, taking into account the quality and quantity of food consumed.

If symptoms of intestinal obstruction occur while taking Panzinorm 10,000 capsules, fibrotic colonopathy should be excluded.

If prolonged use, iron preparations are prescribed at the same time.

Impact on the ability to drive and other mechanical devices: No data on adverse effects on the ability to drive and operate other mechanisms.

Contraindications

Side effects

Allergic reactions: hypersensitivity reactions, including skin hyperemia, skin rash, skin itching; airway obstruction.

Digestive system disorders (when taking high doses of the drug): nausea, vomiting, abdominal pain (including colic), diarrhea, constipation, perianal irritation, irritation of the oral mucosa.

In cystic fibrosis, the development of strictures (fibrous colonopathy) in the ileocecal region and in the ascending colon is rarely possible if the required dose of pancreatin (more than 10,000 UF of lipase per 1 kg of body weight) is exceeded.

Others: hyperuricemia, hyperuricosuria, folate deficiency.

Overdose

Symptoms: nausea, vomiting, diarrhea, hyperuricosuria, hyperuricemia, perianal irritation; fibrous colonopathy rarely develops (in cystic fibrosis).

Treatment: drug withdrawal, hydration, symptomatic therapy.

Pregnancy use

The use of Panzinorm 10 000 during pregnancy and lactation (breastfeeding) is possible only if the expected positive effect of therapy exceeds the possible risk, due to the lack of clinical data confirming the safety of pancreatic enzymes in this category of patients.

It is contraindicated in children under 3 years of age.

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