Pantogam, tablets 500 mg 50 pcs

The spectrum of action of Pantogam® is due to the presence of gamma-aminobutyric acid (GABA) in its structure. The mechanism of action is due to the direct effect of the drug on the GABA-receptor-channel complex.

It has nootropic and anticonvulsant effect. It increases resistance of the brain to hypoxia and toxic substances, stimulates anabolic processes in neurons, combines moderate sedative action with a mild stimulating effect, reduces motor excitability and activates mental and physical performance.

It improves the metabolism of GABA during chronic alcohol intoxication and after withdrawal of ethanol. It is able to inhibit acetylation reactions involved in the inactivation mechanisms of procaine (novocaine) and sulfonamides, thus prolonging the action of the latter. It causes inhibition of pathologically increased bladder reflex and detrusor tone.

Pharmacokinetics

Pantogam® is quickly absorbed from the gastrointestinal tract, passes through the BBB, the highest concentrations are formed in the liver, kidneys, stomach wall and skin.

It is not metabolized and excreted unchanged within 48 hours: 67.5% of the administered dose is excreted in the urine, 28.5% – in the feces.

Indications

Active ingredient

Composition

Active ingredient:

calcium hopantenate (Pantogam®) 250 and 500 mg;

Ancillary substances:

methylcellulose,

calcium stearate,

magnesium hydroxycarbonate,

talk

How to take, the dosage

Adults: single dose – 0.25-1 g, daily – 1.5-3 g, children: single dose – 0.25-0.5 g, daily – 0.75-3 g. The course of treatment – 1-4 months, in some cases – up to 6 months. After 3-6 months repeated course of treatment is possible.

In case of epilepsy in combination with anticonvulsants – 0.75-1 g/day. The course of treatment is up to 1 year or more.

In extrapyramidal neuroleptic syndrome in combination with ongoing therapy, the daily dose is up to 3 g, treatment for several months.

In extrapyramidal hyperkinesias in patients with hereditary diseases of the nervous system (combined treatment) – 0.5-3 g/day. The course of treatment is up to 4 months and more.

In case of sequelae of neuroinfections and traumatic brain injury – 0.25 g 3-4 times a day.

To restore the ability to work at high loads and asthenic conditions – 0.25 g 3 times a day.

For the treatment of extrapyramidal syndrome caused by taking neuroleptics: for adults 0.5-1 g 3 times a day; for children – 0.25-0.5 g 3-4 times a day. The course of treatment is 1-3 months.

In case of tics: in children – 0.25-0.5 g 3-6 times a day, for 1-4 months.

In case of urinary disorders: adults – 0.5-1 g 2-3 times a day; children – 0.25-0.5 g (daily dose – 25-50 mg/kg). The course of treatment is 1-3 months.

In children with various pathologies of nervous system, depending on the age, the drug is recommended in dose 1-3 g. Tactics of prescription: dose build-up within 7-12 days, taking maximum dose for 15-40 days and gradual decrease of dose during 7-8 days of withdrawal of Pantogam®. As for any other nootropic medicine, a break between courses of doses of Pantogam® is from 1 to 3 months.

Interaction

Prolongs the effect of barbiturates, increases the effect of anticonvulsants, prevents the side effects of phenobarbital, carbamazepine, neuroleptics.

Potentiates the effect of local anesthetics (procaine).

The effect of Pantogam® is enhanced in combination with glycine, etidronic acid (xydiphone).

Contraindications

Side effects

Allergic reactions: rhinitis, conjunctivitis, skin rashes are possible.

Others: sleep disturbances or drowsiness, tinnitus may occur (these symptoms are usually transient and do not require withdrawal of the drug).

Overdose

Symptoms: intensification of symptoms of side effects (sleep disturbance or drowsiness, head noise).

Treatment: administration of activated charcoal, gastric lavage, symptomatic therapy.

Similarities