Pantocalcin, tablets 250 mg 50 pcs

Pantocalcin is a nootropic.

Pharmacodynamics

The spectrum of action is due to the presence of GABA in the structure. The mechanism of action is due to the direct effect of the drug Pantocalcin^® on GABA_B-receptor-channel complex. It has neurometabolic, neuroprotective and neurotrophic properties.

Enhances resistance of the brain to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons. It has anticonvulsant effect, reduces motor excitability with simultaneous ordering of behavior. Improves mental and physical performance.

It promotes normalization of GABA in chronic alcohol intoxication and subsequent withdrawal of ethanol.

It shows analgesic effect.

It is able to inhibit acetylation reactions participating in the inactivation mechanisms of novocaine and sulfonamides due to which the prolongation of their action is achieved. It causes inhibition of pathologically increased bladder reflex and detrusor tone.

Pharmacokinetics

In oral administration, it is rapidly absorbed from the gastrointestinal tract. T_max in blood plasma is 1 h. The highest concentrations are formed in the liver, kidneys, gastric wall, skin. It penetrates through the BBB. It is not metabolized and excreted unchanged in 48 hours (67.5% of the taken dose – in the urine, 28.5% – in the faeces).

Indications

cognitive impairment in organic brain lesions and neurotic disorders;
as part of complex therapy for cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels; senile dementia (initial form), residual organic brain damage in mature and elderly people;
cerebral organic failure in patients with schizophrenia (in combination with antipsychotics, antidepressants);
extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (including Huntington’s chorea, hepatocerebral dystrophy, Parkinson’s disease);
consequences of neuroinfections and traumatic brain injuries (as part of complex therapy);
correction and prevention (cover-up therapy with simultaneous prescription) of side effects of antipsychotics; extrapyramidal neuroleptic syndrome (hyperkinetic and akinetic);
epilepsy with slowing of mental processes (in combination with anticonvulsants);
psycho-emotional overload, decreased mental and physical performance; to improve concentration and memory;
urinary disorders: enuresis, daytime urinary incontinence, pollakiuria, urgency;

Children:

mental retardation (delayed mental, speech, motor development or a combination thereof);
cerebral palsy;
stuttering (mainly clonic form);
epilepsy (as part of combination therapy with anticonvulsants, especially for polymorphic seizures and petit mal seizures).

Pharmacological effect

Pantocalcin is a nootropic.

Pharmacodynamics

The spectrum of action is associated with the presence of GABA in the structure. The mechanism of action is due to the direct effect of the drug Pantocalcin® on the GABAB receptor-channel complex. It has neurometabolic, neuroprotective and neurotrophic properties.

Increases the brain’s resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons. It has an anticonvulsant effect, reduces motor excitability while regulating behavior. Increases mental and physical performance.

Helps normalize GABA content during chronic alcohol intoxication and subsequent ethanol withdrawal.

Shows analgesic effect.

It is capable of inhibiting acetylation reactions involved in the mechanisms of inactivation of novocaine and sulfonamides, thereby prolonging the action of the latter. Causes inhibition of the pathologically increased bladder reflex and detrusor tone.

Pharmacokinetics

When taken orally, it is quickly absorbed from the gastrointestinal tract. Tmax in blood plasma is 1 hour. The highest concentrations are created in the liver, kidneys, stomach wall, and skin. Penetrates through the BBB. It is not metabolized and is excreted unchanged within 48 hours (67.5% of the dose taken in urine, 28.5% in feces).

Active ingredient

Hopantenic acid

Composition

1 tablet contains:
active ingredient:
hopantenic acid – 250.00 mg or 500.00 mg;
excipients:
magnesium hydroxycarbonate, calcium stearate, talc, potato starch.

Pregnancy

Contraindicated in the first trimester of pregnancy.

Contraindications

hypersensitivity;
acute renal failure;
pregnancy (first trimester).

Side Effects

Allergic reactions are possible (rhinitis, conjunctivitis, skin rashes).

Interaction

Prolongs the effect of barbiturates; enhances the effects of drugs that stimulate the central nervous system, anticonvulsants, and the effect of local anesthetics (procaine).

Prevents the side effects of the following drugs: phenobarbital, carbamazepine, antipsychotics (neuroleptics).

The effect of hopantenic acid is enhanced in combination with glycine and xydiphone.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

4 years

Manufacturer

Valenta Pharm JSC, Russia