Panangin, concentrate 45.2 mg/ml+40 mg/ml 10 ml 5 pcs

Pharmacotherapeutic group: potassium and magnesium drug.

ATC code: A12CX

Pharmacological properties

Panangin is a source of important electrolytes: potassium and magnesium ions. One of the most important functions of potassium ions is to maintain the membrane potential of neurons, myocytes and excitable structures of myocardial tissue. An imbalance between intracellular and extracellular potassium results in decreased cardiac contractility, arrhythmias, tachycardia and increased toxicity of cardiac glycosides.

Magnesium is an important cofactor of over 300 enzymatic reactions, including energy metabolism and the synthesis of proteins and nucleic acids. In addition, magnesium plays an important role in heart function: it improves contractility and heart rate, resulting in lower myocardial oxygen requirements.

Decreasing the contractility of arteriolar smooth myocytes leads to vasodilation, including of coronary vessels, and increases coronary blood flow. Magnesium has an anti-ischemic effect on myocardial tissue.

The combination of potassium and magnesium ions in one product is based on the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction of the levels of both ions. Further, if the levels of these electrolytes are corrected simultaneously an additive effect is observed (low levels of potassium and/or magnesium have a proarrhythmogenic effect). In addition, potassium and magnesium reduce the toxicity of cardiac glycosides without affecting the positive inotropic effect of the latter.

Pharmacokinetics

No data.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Hypersensitivity to the drug, acute and chronic renal failure; Addison’s disease; atrioventricular block of degree II, III; cardiogenic shock (blood pressure Caution

Atrioventricular block of degree I, marked liver function disorders; metabolic acidosis; danger of oedema; renal disorders if regular monitoring of serum magnesium is not possible (danger of cumulation, toxic levels of magnesium); cardiogenic shock (systolic blood pressure less than 90 mm Hg); hypothyroidism (high blood pressure of >90 mm Hg). Hg); hypophosphatemia; urolithiasis associated with impaired calcium, magnesium and ammonium phosphate metabolism.

Side effects

Overdose

Pregnancy use

Similarities