Panangin, 158 mg+140 mg 50 pcs.

Indications

Tachycardia, Heart Failure

As an adjunctive agent in the treatment of chronic heart disease (heart failure, condition after myocardial infarction), heart rhythm disorders (primarily ventricular arrhythmias), in the treatment of digitalis;

Preferral therapy for magnesium/potassium deficiency in food.

Active ingredient

Potassium and magnesium asparaginate

Composition

Active ingredients:
Magnesium asparaginate 140.0 mg (in the form of magnesium asparaginate-4 H2O – 175.00 mg) and potassium asparaginate 158.0 mg (in the form of potassium asparaginate-1/2 H2O – 166.30 mg).

Auxiliary substances:
Silicon dioxide, colloidal – 2.00 mg, povidone K30 – 3.30 mg, magnesium stearate – 4.00 mg, talc – 10.00 mg, corn starch – 86.10 mg, potato starch – 3.30 mg in the core of tablets.

Shell composition:
Macrogol 6000 – 1.40 mg, titanium dioxide Color ind. 77891, E171 – 5.30 mg, butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate copolymer [1:2:1]
– 6.00 mg, talc – 7.30 mg.

How to take, the dosage

Consult a doctor before use.

Overly, the drug should be used after meals, because the acidic environment of the stomach reduces its effectiveness.

The usual daily dose is 1-2 tablets 3 times a day. Maximum daily dose: 3 tablets 3 times a day.

The duration of the drug and the need for repeated courses is determined by the doctor.

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Interaction

Pharmacodynamic: combined use with potassium-saving diuretics (triamterene, spironolactone), beta-adrenoblockers, cyclosporine, heparin, angiotensin-converting enzyme inhibitors (ACE), nonsteroidal anti-inflammatory drugs increases the risk of hyperkalemia up to arrhythmia and asystole. The use of potassium preparations together with glucocorticosteroids eliminates hypokalemia caused by the latter. Under the influence of potassium, undesirable effects of cardiac glycosides are reduced. It enhances the negative dromo- and batmotropic effect of antiarrhythmic drugs. Magnesium reduces the effects of neomycin, polymyxin B, tetracycline and streptomycin. Anesthetics increase CNS suppressive effect of magnesium preparations; simultaneous use with atracuronium, decamethonium, succinyl chloride
and suxamethonium may increase neuromuscular blockade; calcitriol increases magnesium content in blood plasma, calcium preparations reduce effect of magnesium preparations.

Pharmacokinetic: binding and enveloping agents decrease absorption of the drug in the gastrointestinal tract and a three-hour interval between oral administration of Panangin® and the listed agents should be observed.

Special Instructions

Patients with diseases accompanied by hyperkalemia require special attention: regular control of the ionogram.

Influence on the ability to drive and perform work associated with increased risk of injury: does not affect the ability to drive and engage in activities requiring high concentration and rapid psychomotor reactions.

Synopsis

Round biconvex film-coated tablets, white or almost white, with a slightly shiny and uneven surface, almost odorless.

Contraindications

High sensitivity to any of the ingredients of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison’s disease, atrioventricular block of degree I-III, cardiogenic shock (blood pressure less than 90 mm Hg), amino acid metabolism disorders, severe myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration.

WARNING
Pregnancy (especially in the first trimester) and lactation.

Side effects

Nausea, vomiting, diarrhea, pancreatic discomfort or burning (in patients with anacidic gastritis or cholecystitis), atrioventricular blockade, paradoxical reaction (increased number of extrasystoles) are possible, Hyperkalemia (nausea, vomiting, diarrhea, paresthesias), hypermagnesemia (redness of face, feeling of thirst, decreased blood pressure, hyporeflexia, respiratory depression, seizures).

Overdose

Symptoms: conduction disturbances (especially with previous pathology of the cardiac conduction system).

Treatment: intravenous calcium chloride; if necessary – hemodialysis and peritoneal dialysis.

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Similarities

Panangin, Asparkam, Potassium and Magnesium Asparaginate, Panangin Forte