Menstrual pain (algodysmenorrhea), Joint pain (arthralgia), Osteoarthritis, Sciatica, Myalgia (muscle pain), Neuritis, Toothache, Lumbago, Pain, Migraine, Flu, Muscle pain (myalgia), Arthrosis and arthritis, Neuralgia (nerve pain), Myositis, HeadacheSymptomatic therapy:
- pain syndrome: headache, migraine, toothache, sore throat, lower back pain, muscle pain, painful menstruation;
- fever syndrome (as a febrifuge): elevated body temperature against colds and flu.
- The drug is intended to reduce pain at the time of use and has no effect on the progression of the disease.
1 tablet contains
How to take, the dosage
Adults (including elderly) are prescribed 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.
Children aged 6-9 years are prescribed 1/2 tablet. 3 – 4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose for children aged 6-9 years is 1/2 tablet (250 mg), the maximum daily dose is 2 tablets (1 g).
Children aged 9-12 years are prescribed 1 tablet up to 4 times per day, if necessary. The interval between the doses should be not less than 4 hours. A single dose (1 tablet) can be taken not more than 4 times (4 tablets) during 24 hours.
It is not recommended to use the preparation more than 5 days as an analgesic and more than 3 days as antipyretic without a prescription and supervision. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.
Prolonged use of paracetamol and other NSAIDs increases the risk of “analgesic” nephropathy and renal papillary necrosis, the onset of terminal renal failure.
The simultaneous use of paracetamol in high doses and salicylates increases the risk of renal or bladder cancer.
Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.
Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.
The drug when taken for a long time increases the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.
Inducers of enzymes of microsomal oxidation in the liver (barbiturates, phenytoin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effect in overdose.
Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects.
Metoclopramide and domperidone increase, and colestyramine reduces the rate of absorption of paracetamol.
Ethanol when used simultaneously with paracetamol promotes acute pancreatitis.
The drug may reduce the activity of uricosuric drugs.
During long-term use in high doses it is necessary to monitor the blood picture.
With caution and only under medical supervision the drug should be used in patients with liver or kidney disease, with simultaneous use of antiemetics (metoclopramide, domperidone) and drugs that lower blood cholesterol (colestyramine).
Paracetamol may be taken occasionally if there is a daily need for analgesics while simultaneously taking anticoagulants.
When testing for uric acid and blood glucose levels, the doctor should be warned about taking Panadol.
To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages and should not be taken by persons prone to chronic alcohol consumption.
White film-coated tablets, capsule shape with a flat edge, on one side of the tablets by embossing the mark in the form of a triangle on the other side – the risk.
Children under 6 years of age; hypersensitivity to the drug components.
Caution should be exercised when using the drug with renal and hepatic impairment, benign hyperbilirubinemia (including Gilbert syndrome).Including Gilbert syndrome), viral hepatitis, glucose-6-phosphate dehydrogenase deficiency, alcoholic liver damage, alcoholism, elderly, pregnancy and lactation.
In the recommended doses, the drug is usually well tolerated.
The drug should be taken only in the recommended doses. If the recommended dose is exceeded, seek medical attention immediately, even if well, because there is a risk of delayed serious liver damage.
Hepatic damage in adults is possible when taking ≥10 g of paracetamol. Administration of ≥5 g of paracetamol may result in liver damage in patients with the following risk factors:long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John’s wort or other drugs that stimulate liver enzymes; regular consumption of alcohol in excessive amounts; possibly having glutathione deficiency (in eating disorders, cystic fibrosis, HIV infection, starvation and exhaustion).
Symptoms of acute paracetamol poisoning are nausea, vomiting, stomach pain, sweating, pale skin. After 1-2 days there are signs of liver damage (pain in the liver area, increased activity of liver enzymes). In severe cases of overdose liver failure develops, acute renal failure with tubular necrosis may develop (including in the absence of severe liver damage), arrhythmia, pancreatitis, encephalopathy and coma. Hepatotoxic effect in adults occurs when taking ≥ 10 g of paracetamol.
Treatment: stop using the drug and seek immediate medical attention. Gastric lavage and intake of enterosorbents (activated charcoal, polyphene); administration of SH-group donators and glutathione synthesis precursors – methionine in 8-9 hours after overdose and N-acetylcysteine in 12 hours. The need for additional therapeutic measures (further methionine administration, intravenous N-acetylcysteine administration) is determined depending on the concentration of paracetamol in blood, as well as on the time elapsed after its administration. Treatment of patients with severe liver dysfunction 24 h after paracetamol administration should be carried out together with specialists of a toxicology center or a specialized department of liver diseases.
The drug should be used with caution and only under medical supervision during pregnancy and lactation.
Efferalgan, Cefekon D, Paracetamol, Paracetamol for children, Paracetamol Renewal, Paracetamol, tablets 500 mg 10 pcs
|Conditions of storage|
The drug should be kept out of reach of children at a temperature not exceeding 25 ° C.
GlaxoSmithKlein Dungarvan Limited, Ireland
GlaxoSmithKlein Dungarvan Limited
Buy Panadol, 500 mg 12 pcs. with delivery to USA, UK, Europe and over 120 other countries.