Oxyfrine, 0.01% drops 5 ml

Pharmacodynamics:

Oxymetazoline belongs to the group of alpha-adrenergic stimulants for local use. It has a vasoconstrictor effect. When administered intranasally it reduces swelling of the mucous membrane of the upper airways and nasal secretions. It restores nasal breathing.

The reduction of mucous membrane edema of the nasal cavity restores aeration of the paranasal sinuses of the middle ear cavity which reduces the likelihood of bacterial complications (maxillary sinusitis otitis media).

In local intranasal application and therapeutic concentrations, it does not irritate and cause nasal mucosal hyperemia.

Oxymetazoline begins to act quickly within minutes. The duration of action is up to 12 hours.

Pharmacokinetics:

Oxymetazoline has no systemic action when administered topically intranasally. The half-life of oxymetazoline when administered intranasally is 35 h. 21% of oxymetazoline is excreted in the urine and about 11% in the feces.

Indications

Active ingredient

Composition

1 ml of the drug contains:

The active ingredient:

Oxymetazoline hydrochloride 0.1 mg

Excipients:

Citric acid anhydrous 0.557 mg

Sodium citrate dihydrate 3.823 mg

Hypnotic compound./p>

Glycerol anhydrous 21, 165 mg

Injection water up to 1 ml

How to take, the dosage

Oxyfrin nasal drops 001% is intended for use in children under 1 year of age.

Intranasally.

In children under 4 weeks of age, 1 drop of the drug is administered in each nasal passage 2-3 times a day. From the 5th week of life and up to 1 year of age – 1 to 2 drops of the drug in each nostril 2-3 times a day.

1 drop of this medicine contains 28 mcg oxymetazoline hydrochloride.

The bottle should be turned upside down before use. The medicine should be applied with the child’s head tilted back.

The following procedure has also been proven effective: Depending on age, 1-2 drops of the product are placed on absorbent cotton and used to clean each nasal passage.

If symptoms increase or do not improve within 3 days, a physician should be consulted. At the recommended dose without consulting a physician, use for no more than 7 days.

Higher doses than the recommended doses should only be used under a physician’s supervision.

In frequent and prolonged use, a “stuffy” feeling in the nose may reappear or worsen. If these symptoms occur, you should stop treatment and see a doctor.

Special Instructions

Avoid getting the drug in the eyes.

The drug should be used individually to avoid spreading infection.

Impact on driving and operating ability

After long-term use of rhinitis remedies containing oxymetazoline in doses higher than recommended, general effects on the cardiovascular system and the central nervous system cannot be excluded.

In these cases, caution should be exercised when driving vehicles and engaging in other potentially hazardous activities requiring increased concentration and rapid psychomotor reactions.

Contraindications

With caution

. In patients with diseases of the cardiovascular system (arterial hypertension, coronary heart disease, chronic heart failure, marked atherosclerosis, tachycardia, arrhythmias), carbohydrate metabolism disorders (diabetes mellitus), thyroid function disorders (hyperthyroidism), pheochromocytoma, chronic renal insufficiency, prostatic hyperplasia with clinical symptoms (urinary retention), increased intraocular pressure, porphyria, as well as in patients taking monoamine oxidase inhibitors during the previous 2 weeks and within 2 weeks after their withdrawal, tricyclic antidepressants, bromocriptine.

Side effects

Burning or dry mucous membranes of the nasal cavity, dry mucous membranes of the mouth and throat; sneezing; increased nasal secretion; nasal bleeding; after the effect of the drug, a feeling of “stuffy” nose (reactive hyperemia).

Side effects due to the systemic action of the drug: increased blood pressure, headache, dizziness, palpitations, tachycardia, restlessness, anxiety, fatigue, drowsiness, sedation, irritability, sleep disturbance (in children), nausea, insomnia, exanthema, visual disturbance (if in the eyes), hallucinations, Quincke’s edema, itching, seizures, respiratory arrest (in infants).

Long-term continuous use of vasoconstrictors may lead to tachyphylaxis, nasal mucosal atrophy, and recurrent nasal mucosal edema (medically-induced rhinitis).

If any of the side effects listed in the instructions worsen or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

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