Oxamp sodium, 0.5 g

Oxamp sodium is a combined antibacterial drug.

Oxacillin is an antibiotic from the group of semisynthetic penicillins. It acts bactericidally by inhibiting the synthesis of the bacterial cell wall. It is resistant to the action of penicillinase. Active against Gram-positive bacteria: Staphylococcus spp. (including penicillinase-producing), Streptococcus spp. Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic bacteria: spore-forming bacilli, Actinomyces spp. Most gram-negative bacteria, rickettsiae, viruses, protozoa, fungi are resistant to oxacillin.

Ampicillin is an antibiotic of the group of semisynthetic penicillins. It acts bactericidally, inhibiting synthesis of the bacterial cell wall. It is active against Gram-positive bacteria: Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp. (including Enterococcus spp.), non-sporulating bacteria (including Listeria monocytogenes); Gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp, Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae.

Ampicillin is destroyed by penicillinase.

The combination of ampicillin with oxacillin is rational because the latter, by inhibiting penicillinase activity, reduces the destruction of ampicillin. The spectrum of action with this combination becomes wider.

– burn disease;

– angina.

Prevention of postoperative complications of surgical interventions.

Prevention and treatment of infections in newborns.

Indications

Prevention of postoperative complications of surgical interventions.

Prevention and treatment of infections in newborns.

Active ingredient

Composition

1 bottle of powder contains:

Active ingredients:

Sodium ampicillin 333.33 mg,

Sodium oxacillin 166.67 mg

How to take, the dosage

Oxamp sodium is administered v/m or intravenously (by trickle or drip).

The single dose for adults is 0.5-1 g, daily dose is 2-4 g.

In newborns, premature infants and children under 1 year of age, the drug is administered in a daily dose of 100-200 mg/kg body weight; 1-7 years old, 100 mg/kg/day; 7-14 years old, 50 mg/kg/day; teenagers over 14 years are prescribed the adult dose.

Intravenous Oxamp sodium is administered for 5-7 days with subsequent transition (if necessary) to intravenous administration.

Special Instructions

Contraindications

Side effects

Allergic reactions: skin rash, urticaria, Quincke’s edema; rarely – anaphylactic shock.

Local reactions: when injected intravenously, phlebitis and periphlebitis may develop; when injected intravenously, pain at the injection site may occur.