Ornidazole-Vertex, 500 mg 10 pcs

Ornidazole is an antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action consists in biochemical reduction of the 5-nitrogroup of ornidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitrogroup of ornidazole interacts with the DNA cells of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of the bacteria.

It is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolitica, Lamblia spp, as well as obligate anaerobes Bacteroides spp. (including Bacteroides fraglis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp, Veillonela spp., Prevotella (P.bivia, P.buccae, P.disiens), and some gram-positive microorganisms (Eubacterium spp., Clostridium). Aerobic microorganisms are not sensitive to ornidazole.

Pharmacokinetics

Gastrointestinal absorption is high, bioavailability is 90%. Binding to plasma proteins is less than 15%.

It is metabolized in the liver by hydroxylation, oxidation and glucuronidation. T1/2 is 12-14 hours.

It penetrates into breast milk and most tissues, passes through the HEB and the placenta. It is excreted as metabolites by kidneys (60-70%) and with feces (20-25%), about 5% of dose is excreted unchanged.

Indications

Intestinal infections, Amebiasis and giardiasis, Trichomoniasis

• trichomoniasis;
• amoebiasis: amebic dysentery, extraintestinal amebiasis (incl.
• giardiasis;
• prevention of infections caused by anaerobic bacteria during colorectal and gynecological operations

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Active ingredient

Ornidazole

Composition

Active ingredient: ornidazole 500 mg;

Excipients:

Lactose (milk sugar),

Microcrystalline cellulose,

povidone (polyvinylpyrrolidone),

sodium lauryl sulfate,

calcium stearate,

colloidal silicon dioxide (aerosil),

primellose (sodium croscarmellose),

Hypromellose (hydroxypropyl methylcellulose),

macrogol 4000 (polyethylene glycol 4000),

talc,

titanium dioxide

How to take, the dosage

Ornidazole is administered orally after meals.

In trichomoniasis: orally 1.5 g once or 1 g in combination with intravaginal injection of 500 mg (vaginal tablets) at night. It is possible to treat for 5 days, prescribing 1 tablet (500 mg) orally 2 times a day (morning and evening), also with the prescription of 1 vaginal tablet of 500 mg at night.

In case of amebic dysentery: to adults and children with body weight over 35 kg – 1.5 g once a day, with body weight over 60 kg – 2 g/day. For children with a body weight of 12-35 kg – 40 mg/kg/day. The course is 3 days.

For treatment of other forms of amoebiasis: adults and children over 12 years old – 0.5 g orally in the morning and in the evening for 5-10 days.

In giardiasis: to adults and children with body weight more than 35 kg – 1.5 g 1 time per day; to children with body weight of 12-35 kg – 40 mg/kg/day. The duration of treatment is 1 to 2 days.

Prophylaxis of infections caused by anaerobic bacteria: 0.5-1 g before surgery, after surgery – 0.5 g 2 times a day for 3-5 days.

Interaction

It enhances the effect of anticoagulants of the coumarin series, prolongs the myorelaxant effect of vecuronium bromide.

Compatible with ethanol (does not inhibit acetaldehyde dehydrogenase) unlike other imidazole derivatives (metronidazole).

Contraindications

• hypersensitivity;
• pregnancy (1st trimester);
• lactation period;
• due to the indivisibility of the dosage form, do not prescribe for children with a body weight less than 12 kg.

With caution: CNS diseases (including epilepsy, multiple sclerosis), liver disease, alcoholism, pregnancy, lactation.

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Side effects

Sleepiness, headache, gastrointestinal dysfunction (including nausea), dizziness, tremor, muscle rigidity, movement coordination disorders, seizures, fatigue, temporary loss of consciousness, sensory or mixed peripheral neuropathy, perversion of taste sensation, changes in the activity of “liver” enzymes, allergic reactions.

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Overdose

Symptoms: epileptiform seizures, depression, peripheral neuritis.

Treatment:symptomatic (diazepam for seizures).

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Similarities

Tiberal, Dasolik, Ornidazole