Omnitus, 0.8 mg/ml syrup 200 ml

Pharmacodynamics Butamirate, the active ingredient of Omnitus®, is an anti-cough agent of central action. It is neither chemically nor pharmacologically related to opium alkaloids. It is not addictive or addictive. Suppresses cough by having a direct effect on the coughing center. It has a bronchodilator effect (dilates the bronchi). Helps ease breathing, improving spirometry (reduces airway resistance) and blood oxygenation (saturates blood with oxygen). Pharmacokinetics Absorption is high. After oral syrup administration with a dose containing 150 mg of butamirate citrate, maximum plasma concentration of the main metabolite (2-phenyl butyric acid) is reached after 1.5 hours and is 6.4 µg/ml. Hydrolysis of butamyrate, initially to 2-phenyl butyric acid and diethylaminoethoxyethanol, begins in plasma. These metabolites also have antitussive activity and, like butamirate, are largely (about 95%) bound to plasma proteins, which determines their long elimination half-life. 2-phenyl butyric acid is partially metabolized by hydroxylation at para-position. No cumulation is observed when taking the drug again. The elimination half-life is 6 hours. Excretion of the three metabolites occurs mainly through the kidneys; after conjugation in the liver, the acidic metabolites are largely bound to glucuronic acid.

Indications

Dry cough of any etiology (colds, flu, whooping cough and other conditions).

Active ingredient

Butamirate

Composition

1 ml of syrup contains:

The active ingredient

Butamirate citrate 0.8 mg;

Excipients

Sorbitol 70% (non-crystallizing) – 405.00 mg,

Glycerol – 290.00 mg,

Sodium saccharin – 0.8 mgbr> Sodium saccharin – 0,60 mg,

Benzoic acid – 1,15 mg,

Vanillin – 0,60 mg,

Anise oil – 0,15 mg,

Ethanol 96% – 3,00 µl,

Sodium hydroxide – 0,10 mg,

Purified water – up to 1,00 ml.

How to take, the dosage

Orally, before meals. The syrup contains 1 measuring spoon (5 ml volume): Children: from 3 to 6 years (15-22 kg) – 2 measuring spoons (10 ml) 3 times a day from 6 to 9 years (22-30 kg) – 3 measuring spoons (15 ml) 3 times a day over 9 years (40 kg) – 3 measuring spoons (15 ml) 4 times a day Adults: – 6 measuring spoons (30 ml) 3 times a day If cough persists more than 5 days after starting treatment, you should consult a doctor. Instructions for opening the bottle The bottle is closed with a lid with a safety device that prevents children from opening it. To open the bottle, you need to press hard on top of the lid and turn it counterclockwise. After use, the bottle must be closed tightly, to do this, the bottle cap must be screwed back on tightly.

Special Instructions

The syrup contains sorbitol and saccharin as sweeteners, so the drug can be used by patients with diabetes.

Synopsis

Transparent, colorless or yellowish, viscous liquid with a smell of vanilla.

Contraindications

Hypersensitivity to the drug components, pregnancy (I trimester), breastfeeding, children under 3 years of age. Fructose intolerance (the drug contains sorbitol).

Side effects

Classification of the frequency of adverse reactions: very frequently (≥1/10), frequently (≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely (≥1/10000, <1/1000), very rarely (<1/10000), including individual cases. Central nervous system: rare – dizziness, somnolence. The digestive system: rare – nausea, diarrhea. Allergic reactions: rare – skin rash, itching, urticaria.

Overdose

Symptoms: nausea, vomiting, drowsiness, diarrhea, dizziness, decreased blood pressure.

Treatment: orally – activated charcoal, saline laxatives, if necessary – symptomatic therapy.

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Pregnancy use

Contraindicated in lactation, first trimester of pregnancy, children and adolescents under 3 years of age.

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Similarities

Sinecode, Codelac Neo, For cough and runny nose