Oftocipro, eye ointment 0.3% 3 g

Oftocipro is an antimicrobial.

Pharmacodynamics

. Broad spectrum antimicrobial, fluoroquinolone derivative, inhibits bacterial DNA-gyrease (topoisomerases II and IV, responsible for DNA unwinding for further transcription process), disrupts DNA synthesis, bacterial growth and division. It acts bactericidally on Gram-negative organisms during quiescence and division, on Gram-positive microorganisms – only during division.

Ciprofloxacin is sensitive to Gram-negative aerobic bacteria: Enterobacteriaceae (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp, Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii, Vibrio spp., Yersinia spp.), other Gram-negative bacteria (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.), some intracellular pathogens (Legionella pneumophila, Brucella spp, Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Corynebacterium diphtheriae); Gram-positive aerobic bacteria:Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae).Most staphylococci resistant to methicillin are also resistant to ciprofloxacin. The sensitivity of Streptococcus pneumoniae, Enterococcus faecalis, Mycobacterium avium(located intracellularly) is moderate (high concentrations are required for their suppression).

Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides are resistant to the drug. Ineffective against Treponema pallidum. Resistance develops very slowly because, on the one hand, after ciprofloxacin action practically no persistent microorganisms remain, and on the other hand, bacterial cells have no enzymes which inactivate it.

Pharmacokinetics

In local administration, systemic absorption is low.

Indications

Eye infections

Any of the listed diseases when the causative agents are bacteria sensitive to the active ingredient:

• acute and subacute conjunctivitis,
• blepharitis,
• blepharoconjunctivitis,keratitis,
• keratoconjunctivitis,
• bacterial corneal ulcer,
• Corneal ulcerChronic dacryocystitis,
• meibomitis,
• infective eye lesions after trauma or foreign bodies,

Pre- and postoperative prevention of infectious complications in ophthalmic surgery.

Active ingredient

Ciprofloxacin

Composition

Active substance:

ciprofloxacin hydrochloride (in terms of ciprofloxacin) 0.3 g

Auxiliary substances:

nipagin (methylparahydroxybenzoate) – 0.2 g;

p> Vaseline medical – 89.55 g;

lanolin anhydrous – 9.95 g

How to take, the dosage

In the conjunctival sac.

Adults and children over 2 years of age. A 1-1.5 cm strip of the ointment is placed behind the lower eyelid of the affected eye 3 times a day for 2 days. Then for 5 days the drug shall be used 2 times a day. If severe infectious process develops, the ointment is applied every 3-4 hours, as inflammation decreases, reduce the frequency of application of the drug. The course of treatment should not exceed 14 days. To apply the ointment carefully pull down the lower eyelid and, pressing lightly on the tube, introduce a strip of ointment into the conjunctival sac. Then slowly release the eyelid and press it with a cotton swab or cotton swab for 1-2 minutes. After that, you should close your eyes for 1-2 minutes.

Interaction

The interaction of Oftotsipro eye ointment with other drugs during concomitant use has not been described.

There is information that systemic use of some quinolones leads to increased plasma concentrations of theophylline, affects caffeine metabolism and enhances the effect of oral anticoagulants (including warfarin and its derivatives).

Transient increases in serum creatinine levels have been reported in patients treated with cyclosporine combined with systemic administration of ciprofloxacin.

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Special Instructions

Wearing contact lenses is not recommended during the treatment with the drug.
When using other ophthalmic drugs the interval between injections should be at least 5 minutes.

Impact on the ability to drive vehicles and operate machinery.

Disability to see may be affected immediately after using the eye ointment and it may cause difficulty in driving vehicles and operating machinery; it is recommended to start working (driving) 15 min after using the drug.

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Contraindications

• hypersensitivity;
• pregnancy;
• lactation period;
• childhood (under 2 years);
• viral and fungal eye lesions.

With caution: in patients with atherosclerosis of cerebral vessels, impaired cerebral circulation, convulsive syndrome.

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Side effects

Allergic reactions, itching, burning, mild conjunctival pain and hyperemia, nausea, rare – eyelid edema, photophobia, lacrimation, foreign body sensation in eyes, unpleasant taste in mouth immediately after application, decreased visual acuity, appearance of white crystal precipitate in patients with corneal ulcer, keratitis, keratopathy, corneal infiltration, development of superinfection.

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Overdose

Inadvertent ingestion does not cause specific symptoms.

Nausea, vomiting, diarrhea, headache, fainting and anxiety may occur.

Treatment: standard first aid measures, adequate fluid intake, creation of an acidic urine reaction to prevent crystalluria.

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Pregnancy use

It is contraindicated in pregnancy, lactation and children under 2 years.

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Similarities

Ciprofloxacin, Ciprolet, Cifran, Ciprofloxacin, Cipromed, Cifran OD, Ciprofloxacin Ecocifol, Ciprofloxacin, Cipromed, Ciprofloxacin Teva, Ciprofloxacin Renewal