Oflomikol, 2% cream 20 g

Pharmacodynamics

Antifungal agent, imidazole and benzothiophene derivative with a broad spectrum of action. Mechanism of action is inhibition of ergosterol synthesis (main sterol of fungus and yeast membranes) and increase of cell membrane permeability, which leads to lysis of fungus cell.

In therapeutic doses it has fungistatic and fungicidal action against pathogenic fungi (Candida spp, including Candida albicans, Candida tropicalis, Pityrosporum orbiculare, Malassezia furfur), dermatophytes (Trichophyton, Microsporum, Epidermophyton floccosum) and is active against pathogens of skin and mucous membrane infections (Gram-positive strains of staphylo- and streptococci).

Pharmacokinetics

Sertaconazole is undetectable in blood and urine when used externally.

Indications

Treatment of superficial skin mycoses: dermatomycosis, Tinea pedis (athlete’s foot), Tinea crusis (groin dermatomycosis), Tinea corporis (smooth skin mycosis), Tinea barbae (beard mycosis), Tinea manus (hand dermatophytosis), candidiasis (Monolisiasis), and Pityiriasis versicolor (Pityrosporum orbiculare) (liverworts).

Active ingredient

Sertaconazole

Composition

1 g of the cream contains:

The active ingredient: sertaconazole nitrate – 0.020 g;

Auxiliary substances:

cetyl alcohol 0.035 g, stearyl alcohol 0.035 g, myristyl alcohol (Sepeziol s 14) 0.020 g, glyceryl monostearate (NSE) 0.020 g, sorbitan stearate 0,010 g, polysorbate-60 (Tween 60) 0.035 g, octyldodecanol 0.040 g, liquid paraffin 0.040 g, benzyl alcohol 0.010 g, purified water 0.735 g.

How to take, the dosage

Externally.

The cream is applied to the affected areas of the skin in an even thin layer twice a day, covering about 1 cm of the healthy skin surface. Before using the product, the skin at the site of application should be cleaned with water and soap and dried.

The duration of treatment depends on the etiology (causative agent) and localization of the infection. As a rule, symptoms disappear after 2-4 weeks. The recommended duration of treatment is 4 weeks.

If after treatment, there is no improvement, or if symptoms get worse or new symptoms develop, a doctor should be consulted.

To use the drug only according to the indication, route of administration, and dosage listed in the leaflet.

Interaction

Interaction with other drugs was not revealed.

Special Instructions

Do not use in ophthalmic practice. After application of the drug it is not recommended to use acidic detergents (in an acidic environment Candida spp. multiplication is increased).

There are no data on the use of the drug in children.

The product contains cetyl alcohol and stearyl alcohol, which may cause local skin reactions (such as contact dermatitis).

The product contains benzyl alcohol, which may cause allergic reactions.

The use of the drug in accordance with the instructions for use does not affect the performance of potentially hazardous activities requiring increased concentration and quick psychomotor reactions (driving, operating moving machinery).

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Synopsis

Homogeneous cream of white color.

Contraindications

Hypersensitivity to sertaconazole and other drug components, including other imidazole derivatives.

Side effects

Contact dermatitis, erythematous reactions at the application site may disappear quickly, which does not require withdrawal of the drug. If you experience or worsen any of the side effects mentioned in the instructions, or if you notice any other side effects not mentioned in the instructions, please inform your doctor.

Overdose

Considering the method of administration, overdose of the drug is unlikely.

In case of accidental ingestion of the drug, symptomatic treatment should be administered.

Pregnancy use

In pregnancy, use only if the estimated benefits to the mother exceed the potential risk to the fetus. During lactation the cream should not be applied to the mammary gland area. If it is necessary to use the drug during lactation, it is necessary to consider stopping breast-feeding.

Please consult your physician before using OPLOMYCOL if you are pregnant, or if you suspect that you may be pregnant, or if you plan to become pregnant.

In breastfeeding, you should consult your doctor before using OFLOMYCOL.

Similarities

Zalain