Ocomistin, eye and ear drops 0.01% 10 ml
€7.85 €6.87
Antiseptic agent
ATH code S01AХ
Pharmacological properties
Pharmacodynamics.
The main active substance of the drug Ocomistin® is antiseptic Benzildimethyl-myristoylamino-propylammonium which has strong antimicrobial activity against Gram-positive and Gram-negative, aerobic and anaerobic bacteria in the form of monocultures and microbial associations, including hospital strains with multiresistance to antibiotics. The drug acts on chlamydiae, pathogenic fungi and herpes and adenoviruses.
The drug is more effective against Gram-positive bacteria including: staphylococci and streptococci.
It has antifungal effect on ascomycetes of the genus Aspergillus and Penicillium, yeasts (Rhodotorula tubra, Torulopsis glabrata) and yeasts (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, T. schoenleini, T. violaceum, Epidermophyton Kaufman-Wolf, E, floccosum, Microsporum gypseum, Microsporum canis) as well as other pathogenic fungi (for example, Pityrosporum orbiculare (Malassezia furfur)) as monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs. Pharmacokinetics.
The drug has local action. There are no data about possible penetration into bloodstream.
Indications
Ophthalmology
Okomistin®, eye, ear, and nasal drops are recommended for use in the complex treatment of infectious processes in the anterior part of the eye (blepharitis, conjunctivitis, keratitis, keratouveitis), eye injuries, eye burns (thermal and chemical); in the preoperative and postoperative periods for the treatment and prevention of purulent-inflammatory eye lesions.
Prevention of ophthalmia of newborns, including gonococcal and chlamydial.
Otorhinolaryngology
The drug is used in the complex treatment of acute sinusitis/rhinosinusitis, exacerbation of chronic sinusitis/rhinosinusitis, acute rhinitis; acute and chronic external otitis, chronic purulent mesotympanitis, otomycosis.
Pharmacological effect
Antiseptic
ATX code S01AX
Pharmacological properties
Pharmacodynamics.
The main active ingredient of the drug Okomistin® is the antiseptic benzyldimethyl-myristoylamino-propylammonium, which has a pronounced antimicrobial effect against gram-positive and gram-negative, aerobic and anaerobic bacteria in the form of monocultures and microbial associations, including hospital strains with multidrug resistance to antibiotics. The drug acts on chlamydia, pathogenic fungi, as well as herpes viruses and adenoviruses.
The drug is more effective against gram-positive bacteria, including: staphylococci, streptococci.
It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillium, yeasts (Rhodotorula tubra, Torulopsis glabrata) and yeasts (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, T. schoenleini, T. violaceum, Epidermophyton Kaufman-Wolf, E, floccosum, Microsporum gypseum, Microsporum canis), as well as other pathogenic fungi (for example, Pityrosporum orbiculare (Malassezia furfur)) in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs.
The action of benzyldimethyl-myristoylamino-propylammonium is based on the direct hydrophobic interaction of the molecule with the lipids of the membranes of microorganisms, leading to their fragmentation and destruction. In this case, part of the benzyldimethyl-myristoylamino-propylammonium molecule, plunging into the hydrophobic portion of the membrane, destroys the supra-membrane layer, loosens the membrane, increases its permeability for large-molecular substances, changes the enzymatic activity of the microbial cell, inhibits enzyme systems, which leads to inhibition of the vital activity of microorganisms and their cytolysis.
Benzyldimethyl-myristoylamino-propylammonium has a high selectivity of action against microorganisms, because has virtually no effect on the membranes of human cells, which is due to the different structure of the latter – the significantly longer length of lipid radicals, which sharply limits the possibility of hydrophobic interaction of benzyldimethyl-myristoylamino-propylammonium with cells. Under the influence of the drug, the resistance of bacteria and fungi to antibiotics is reduced.
Benzyldimethyl-myristoylamino-propylammonium has anti-inflammatory and immunoadjuvant effects, enhances local protective reactions, regenerative processes, activates nonspecific defense mechanisms due to modulation of the cellular and local humoral immune response.
Pharmacokinetics.
The drug has a local effect. There are no data on possible penetration into the bloodstream.
Special instructions
Contact lenses should be removed immediately before instillation of Okomistin® and put on no earlier than 15 minutes after instillation.
To avoid contamination and cross-infection, do not use the same vial to treat eye, nose, and/or ear infections at the same time. To prevent contamination of the drug solution during instillation, patients should avoid contact of the dropper tip with the eye and skin.
Sharing the dropper bottle by more than one person may spread the infection.
Impact on the ability to drive vehicles and machinery
After using the drug, a temporary decrease in the clarity of visual perception is possible and until it is restored, it is not recommended to drive a car or engage in activities that require increased attention and reaction.
Active ingredient
Benzyldimethylmyristoylaminopropylammonium
Composition
Composition per 100 ml
Active substance:
Benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate (calculated as an anhydrous substance) – 0.01 g
Excipients:
sodium chloride – 0.90 g,
purified water up to 100 ml
Pregnancy
The use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus and child.
Contraindications
Individual sensitivity to the components of the drug.
Side Effects
Allergic reactions are possible. In some cases, a slight burning sensation and discomfort may occur, which go away on their own after 15-20 seconds and do not require discontinuation of the drug.
If any adverse events occur, you should consult a doctor.
Interaction
When used together, Okomistin® increases the effectiveness of topical antibiotics.
Interaction studies of the drug with other drugs have not been conducted.
Overdose
Not observed.
Storage conditions
Store at a temperature not exceeding 25°C.
Keep out of the reach of children.
Shelf life
3 years.
Shelf life after opening – 1 month.
Do not use after expiration date.
Manufacturer
Infamed K, Russia
Shelf life | 3 years. Shelf life after opening – 1 month. Do not use after the expiration date. |
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Conditions of storage | Store at a temperature not exceeding 25 ° C. Keep out of reach of children. |
Manufacturer | Infamed K, Russia |
Medication form | eye and ear drops |
Brand | Infamed K |
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