Novocaine, rectal 100 mg 10 pcs

Novocaine is a local anesthetic.

It accumulates in the membranes of nerve fibers and endings and interacts with receptors located in potential-dependent sodium channels.

Maintains membrane permeability to sodium ions, preventing the onset of an action potential and the conduction of the pain impulse.

Indications

Infiltration, conduction, epidural and spinal anesthesia; vagosympathetic and paranephral blockade; pain syndrome in gastric and duodenal ulcers, hemorrhoids, nausea.

Active ingredient

How to take, the dosage

Preliminary release the candle from the contour pack with scissors (by cutting the pack along the contour of the candle) and insert it deep into the anus (after a purging enema or spontaneous release of the bowels) 1-2 times a day.

Interaction

Prolongs neuromuscular blockade caused by suxamethonium (because both drugs are hydrolyzed by plasma cholinesterase).

The use simultaneously with MAO inhibitors (furazolidone, procarbazine, selegelin) increases the risk of arterial hypotension. Procaine toxicity is increased by anticholinesterase drugs (which inhibit its hydrolysis). Metabolite of procaine (para-aminobenzoic acid) is a competitive antagonist of sulfonamide preparations and can weaken their antimicrobial effect.

The treatment of the injection site of the local anesthetic with disinfectant solutions containing heavy metals increases the risk of local reaction in the form of soreness and swelling.

Potentiates the effect of direct anticoagulants.

Preprat reduces the effect of anticholinesterase agents on neuromuscular transmission.

Cross-sensitization is possible.

Contraindications

Hypersensitivity.

Side effects

Dizziness, weakness, hypotension, allergic reactions.

Overdose

Symptoms: pallor of skin and mucous membranes, dizziness, nausea, vomiting, increased nervous excitability, cold sweat, tachycardia, decreased blood pressure almost to collapse, tremor, seizures, apnea, methemoglobinemia, respiratory depression, sudden cardiovascular collapse.
Action on the central nervous system is manifested by feelings of fear, hallucinations, seizures, motor agitation. In case of overdose the drug administration should be immediately stopped. In case of local anesthesia the site of injection may be injected with adrenaline.

Treatment: general resuscitation measures, including oxygen inhalation, if necessary, artificial lung ventilation. If convulsions lasted more than 15-20 seconds, they were stopped by intravenous thiopental (100-150 mg) or diazepam (5-20 mg). In arterial hypotension and/or myocardial depression, ephedrine (15-30 mg) shall be administered intravenously, in severe cases, detoxification and symptomatic therapy.
If intoxication develops after Novocaine injection in the leg or arm muscles, urgent tourniquet application is recommended to reduce the subsequent entry of the drug into the general bloodstream.

Similarities