Novocaine, 5 mg/ml 5 ml 10 pcs

Novocaine is a local anesthetic.

It accumulates in the membranes of nerve fibers and endings and interacts with receptors located in potential-dependent sodium channels.

Decreases membrane permeability to sodium ions, preventing the onset of an action potential and the conduction of the pain impulse.

Indications

Active ingredient

Composition

Active substances:

procaine hydrochloride 5 mg

How to take, the dosage

Novocaine is administered intramuscularly – 5-10 ml of 1-2% solution 3 times a week for a month, followed by a 10-day break; for infiltration anesthesia 0.25-0.5% solutions are used, for percutaneous – 2% solution.

Internal administration – 1/2 tsp (in pain).

Interaction

Prolongs neuromuscular blockade caused by suxamethonium (because both drugs are hydrolyzed by plasma cholinesterase).

The use simultaneously with MAO inhibitors (furazolidone, procarbazine, selegelin) increases the risk of arterial hypotension. Procaine toxicity is increased by anticholinesterase drugs (which inhibit its hydrolysis). Metabolite of procaine (para-aminobenzoic acid) is a competitive antagonist of sulfonamide preparations and can weaken their antimicrobial effect.

The treatment of the injection site of the local anesthetic with disinfectant solutions containing heavy metals increases the risk of local reaction in the form of soreness and swelling.

Potentiates the effect of direct anticoagulants.

Preprat reduces the effect of anticholinesterase agents on neuromuscular transmission.

Cross-sensitization is possible.

Special Instructions

During treatment, caution should be exercised when driving motor vehicles and engaging in other potentially hazardous activities that require increased concentration and quick psychomotor reactions.

Patients require monitoring of cardiovascular, respiratory and central nervous system functions. Monoamine oxidase inhibitors should be discontinued 10 days prior to local anesthetic administration.

Contraindications

Hypersensitivity.

Side effects

Overdose

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, increased nervous excitability, cold sweats, tachycardia, decreased blood pressure almost to collapse, tremors, seizures, apnea, methemoglobinemia, respiratory depression, sudden cardiovascular collapse.

The effect on the central nervous system is manifested by feelings of fear, hallucinations, seizures, motor agitation. In cases of overdose the drug administration should be stopped immediately. In case of local anesthesia the site of injection may be injected with adrenaline.

Treatment: general resuscitation measures, including oxygen inhalation, if necessary, artificial lung ventilation. If convulsions lasted more than 15-20 seconds, they were stopped by intravenous thiopental (100-150 mg) or diazepam (5-20 mg). In arterial hypotension and/or myocardial depression, ephedrine (15-30 mg) shall be administered intravenously; in severe cases, detoxification and symptomatic therapy shall be administered.

In case of development of intoxication after an injection of novocaine in the muscle of the leg or arm, an urgent tourniquet is recommended to reduce the subsequent entry of the drug into the general bloodstream.

Similarities