Novocaine, 5 mg/ml 10 ml 10 pcs

Novocaine is a local anesthetic.

It accumulates in the membranes of nerve fibers and endings and interacts with receptors located in potential-dependent sodium channels.

Decreases membrane permeability to sodium ions, preventing the onset of an action potential and the conduction of the pain impulse.

Indications

various types of local anesthesia,
anal fissures,
haemorrhoids.

Pharmacological effect

Novocaine is a local anesthetic.

It accumulates in the membranes of nerve fibers and endings and interacts with receptors located in voltage-gated sodium channels.

Reduces the permeability of membranes to sodium ions, preventing the occurrence of action potentials and the conduction of pain impulses.

Special instructions

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Patients require monitoring of the functions of the cardiovascular system, respiratory system and central nervous system. Monoamine oxidase inhibitors should be discontinued 10 days before the local anesthetic is administered.

Active ingredient

Procaine

Composition

Active ingredients:

procaine hydrochloride 5 mg

Contraindications

Hypersensitivity.

Side Effects

dizziness,
weakness,
hypotension,
allergic reactions.

Interaction

Prolongs the neuromuscular blockade caused by suxamethonium (since both drugs are hydrolyzed by plasma cholinesterase).

Use simultaneously with MAO inhibitors (furazolidone, procarbazine, selegeline) increases the risk of developing arterial hypotension. The toxicity of procaine is increased by anticholinesterase drugs (suppressing its hydrolysis). The metabolite of procaine (para-aminobenzoic acid) is a competitive antagonist of sulfonamide drugs and can weaken their antimicrobial effect.

When treating the injection site of a local anesthetic with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of pain and swelling increases.

Potentiates the effect of direct anticoagulants.

The drug reduces the effect of anticholinesterase drugs on neuromuscular transmission.

Cross-sensitization is possible.

Overdose

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, increased nervous excitability, cold sweat, tachycardia, decreased blood pressure almost to the point of collapse, tremor, convulsions, apnea, methemoglobinemia, respiratory depression, sudden cardiovascular collapse.

The effect on the central nervous system is manifested by a feeling of fear, hallucinations, convulsions, and motor agitation. In cases of overdose, administration of the drug should be stopped immediately. When performing local anesthesia, the injection site can be injected with adrenaline.

Treatment: general resuscitation measures, which include oxygen inhalation, and, if necessary, artificial ventilation. If convulsions continue for more than 15-20 seconds, they are stopped by intravenous administration of thiopental (100-150 mg) or diazepam (5-20 mg). For arterial hypotension and/or myocardial depression, ephedrine (15-30 mg) is administered intravenously; in severe cases, detoxification and symptomatic therapy.

If intoxication develops after injection of novocaine into the muscles of the leg or arm, it is recommended to urgently apply a tourniquet to reduce the subsequent entry of the drug into the general bloodstream.

Storage conditions

In a place protected from light, at a temperature not exceeding 20 °C.

Shelf life

3 years

Manufacturer

Dalkhimfarm, Russia