Novigan, 10 pcs.

Pharmacodynamics

Combination drug, has analgesic, anti-inflammatory and antispasmodic effects. Inhibits the synthesis of prostaglandins (Pg). The drug contains a non-steroidal anti-inflammatory agent – ibuprofen, myotropic antispasmodic agent – pitofenone hydrochloride and m-cholin-blocking agent of central and peripheral action – phenpiveryinia bromide.

Indications

Active ingredient

How to take, the dosage

Interaction

In therapeutic doses Novigan® has no significant interactions with commonly used drugs.

The inducers of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication.

Microsomal oxidation inhibitors reduce the risk of hepatotoxic effects.

Decreases the hypotensive activity of vasodilators and the natriuretic effect of furosemide and hydrochlorothiazide.

Decreases the effectiveness of uricosuric drugs.

Accelerates the effect of indirect anticoagulants, antiaggregants, fibrinolytics (which increases the risk of bleeding).

Accelerates the side effects of mineralocorticosteroids, GCS (increased risk of gastrointestinal bleeding), estrogen, ethanol; increases the hypoglycemic effect of sulfonylurea derivatives.

Antacids and colestiramine decrease absorption of ibuprofen.

Enhances blood concentrations of digoxin, lithium drugs and methotrexate.

It increases the effect of m-cholinoblockers, H1-histamine receptor blockers, butyrophenones, phenothiazines, amantadine and quinidine.

The concomitant administration of other NSAIDs increases the frequency of side effects.

Caffeine increases the analgesic (analgesic) effect.

When taken concomitantly it reduces anti-inflammatory and antiaggregant effect of acetylsalicylic acid (increased incidence of acute coronary failure is possible in patients receiving low doses of acetylsalicylic acid as an antiaggregant after initiation of Novigan® administration).

Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin increase the incidence of hypoprothrombinemia when administered simultaneously.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Cyclosporine and gold drugs increase the effect of ibuprofen on PG synthesis in kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.

Like drugs that block tubular secretion decrease excretion and increase the plasma concentration of ibuprofen.

Special Instructions

Contraindications

Side effects

Overdose

Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased BP, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.

The treatment: gastric lavage (only within one hour after ingestion), prescription of activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy (correction of acid-base status, BP). There is no specific antidote to the drug.

Do not exceed the recommended doses. If the recommended doses are exceeded, seek immediate medical attention or contact the nearest medical facility (bring the drug package with you).

Similarities