Normomed, tablets 500 mg 20 pcs
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ATX code: J05AX05
Pharmacological properties
Pharmacodynamics
Inosin Pranobex is a synthetic purine derivative, is a complex containing inosin and N,N-dimethylamino-2-propanol in a molar ratio of 1:3. It has immunostimulating activity and nonspecific antiviral action. The effectiveness of the complex is determined by the presence of inosin, the second component increases its availability to lymphocytes.
It restores lymphocyte functions under immunosuppression, increases blastogenesis in monocyte population, stimulates membrane receptor expression on the surface of T-helpers, prevents decrease in lymphocyte activity under glucocorticosteroids influence, normalizes thymidine induction into lymphocytes. Inosin Prepobex stimulates T-lymphocytes activity and natural killer cells, T-suppressor and T-helper functions, increases immunoglobulin G (Ig G), interferon-gamma production, IL-1 and IL-2, decreases anti-inflammatory cytokines formation -I J1-4 and IL-10, potentiates neutrophils, monocytes and macrophages chemotaxis.
The preparation shows antiviral activity in vivo against herpes simplex virus, cytomegalovirus, measles virus, human T-cell lymphoma virus (Tin III), polioviruses, influenza A and B viruses, human EHV (EHV), encephalomyocarditis and horse encephalitis viruses. The mechanism of antiviral action of Pranobex inosine is associated with inhibition of viral RNA and dihydropteroatetase involved in the replication of some viruses, it increases the suppressed viral mRNA synthesis of lymphocytes, which is accompanied by reduction of viral RNA synthesis and translation of viral proteins, increases production of alpha and gamma interferons having antiviral properties by lymphocytes. In combination treatment it increases the effect of interferon-alpha, acyclovir and zidovudine.
Pharmacokinetics
After oral administration the drug is well absorbed from the gastrointestinal tract (GIT). Maximum concentration of ingredients in blood plasma is determined after 1-2 hours. It is rapidly metabolized and excreted through the kidneys. It is metabolized similarly to endogenous puripose nucleotides with formation of uric acid. N,N-dimethylamino-2-propanol is metabolized to N-oxide, and 4-acetamidobenzoate to o-acylglucuropide. No cumulation of the drug in the body has been detected. The elimination half-life (T1/2) is 3.5 h for N,N -dimethylamino-2-propanol and 50 min for 4-acetamidobenzoate. The drug and its metabolites are eliminated from the body by the kidneys within 24-48 hours.
Indications
Active ingredient
Composition
How to take, the dosage
Interaction
Special Instructions
Synopsis
Contraindications
Cautions
Cautions should be taken when concomitantly prescribing with xaptinoxidase inhibitors, diuretics, zidovudine, acute hepatic failure.
Side effects
Overdose
Pregnancy use
Similarities
Weight | 0.100 kg |
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Shelf life | 3 years. |
Conditions of storage | In the dark place at a temperature no higher than 30 ° C. Keep out of reach of children. |
Manufacturer | Obninsk HFC, Russia |
Medication form | pills |
Brand | Obninsk HFC |
Other forms…
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