Normomed syrup 50 mg/ml, 180 ml

Name: Normomed syrup 50 mg/ml, 180 ml
SKU: 294116
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EAN: 8022086001315 SKU: 294116 Categories: Immune system, Immunostimulants, Medicine

Description

– Treatment of influenza and other acute respiratory infections;

– immunodeficiency conditions caused by viral infections in patients with normal and weakened immune systems, including diseases caused by Herpes simplex (type I and type II, genital herpes and other localized herpes);

– subacute sclerosing panencephalitis.

Active ingredient

Inosyn Pranobex

Composition

On 100 ml of syrup:

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Active substance:
	Inosine pranobex 5.00 g
Associates:
Saccharose	65.00 g
Glycerol	5.00 g
Methyl parahydroxybenzoate	0.18 g
Propylparahydroxybenzoate	0.02 g
Citrus flavoring	0.50 g
Water purified	up to 100 ml

Interaction

Immunosuppressants weaken the immunostimulatory effect of the drug.

The drug should be used with caution in patients taking xanthine oxidase inhibitors (aplopurinol) or loop diuretics (furosemide, thorasemide, etacrynic acid) simultaneously, since this may lead to increased serum uric acid concentration.

Co-administration of the drug with zidovudine leads to increased concentration of zidovudine in blood plasma and prolongs its T1/2. Thus, when co-administering the drug with zidovudine, the dose of zidovudine may need to be adjusted.

Directions for use

Overly, after meals, with a small amount of water, at regular intervals (8 or 6 hours) 3-1 times a day.

The dosing regimen is adjusted individually, depending on the age and body weight, as well as on the severity of the disease.

Adults and children over 12 years of age: on the basis of 50 mg per 1 kg of body weight, up to a maximum of 4 g per day. Usually 20 ml of syrup 3-4 times a day is prescribed.

Children from 3 to 12 years of age: 50 mg per 1 kg of body weight per day, divided into 3-4 doses.

Adults and children with severe infectious diseases: the dose can be increased to 100 mg/kg/day, in 4-6 doses. The maximum daily dose in adults is 3-4 g per day, in children – 50 mg/kg/day.

In acute diseases: treatment usually lasts from 5 to 14 days. After disappearance of symptoms, treatment should be continued for 1-2 days or longer, depending on indications.

In chronic relapsing disease: treatment in adults and children is carried out in courses of 5-10 days at intervals of 8 days. The duration of maintenance treatment can be up to 30 days, and the dose can be reduced to 500-1000 mg/day.

Treatment of infections caused by the herpes virus in adults and children: Several courses of 5-10 days should be taken until symptoms disappear.

Patient special groups

Perhaps older patients. There is no need to adjust the dose; the drug is used the same way as in middle-aged patients. Elderly patients are more likely to have increased uric acid concentrations in serum and urine than middle-aged patients.

Application in children. It is used in children over 3 years old.

The use in patients with renal and hepatic impairment. During the treatment by Normomed® it is necessary to control the uric acid content in blood serum and urine every 2 weeks. Control of liver enzymes activity is recommended every 4 weeks during long-term treatment with the drug.

Special Instructions

Consult a doctor before starting treatment.

Normomed® as well as other antiviral drugs are most effective in acute viral infections if the treatment is started at the early stage of the disease (better from the first day).

Since inosine is excreted from the body in the form of uric acid, during long-term use it is recommended to monitor the uric acid concentration in blood serum and urine periodically. Patients with significantly elevated uric acid concentration in the body may simultaneously take drugs that reduce its concentration.

It is necessary to monitor the concentration of uric acid in serum when prescribing the drug simultaneously with the drugs that increase the concentration of uric acid or the drugs that impair renal function.

Normomed® should be used with caution in patients with acute hepatic failure, since the drug is metabolized in the liver.

Impact on the ability to operate vehicles and moving mechanisms:

The effect of the drug on psychomotor functions of the body and the ability to operate vehicles and moving mechanisms has not been studied. When using the drug, the possibility of dizziness and somnolence should be taken into account.

Contraindications

– Hypersensitivity to pranobex inosine and other components of the drug;

– gout;

– urolithiasis;

– Chronic renal failure;

– arrhythmias;

– pregnancy;

– breastfeeding period;

– children under 3 years of age (body weight under 15-20 kg).

With caution:
Concurrent administration with xanthine oxidase inhibitors, diuretics, zidovudine; in acute hepatic failure

Side effects

Side effects are defined as follows: frequently – >1/100 and <1/10; and infrequently – >1/1000 and <1/100.

Nervous system disorders: frequent – headache, dizziness, fatigue, malaise; infrequent – nervousness, drowsiness, insomnia.

Gastrointestinal tract: often – decreased appetite, nausea, vomiting, epigastric pain; infrequent – diarrhea, constipation.

Hepatobiliary system disorders: often – increase of liver enzymes activity, alkaline phosphatase.

Skin and subcutaneous fatty tissue: often – itching, rash.

Renal and urinary tract: infrequent – polyuria.

Allergic reactions: infrequent – maculopapular rash, urticaria, angioedema.

General disorders: often – pain in the joints, exacerbation of gout.

Laboratory and instrumental data: frequently – increase in blood urea nitrogen concentration.

Overdose

In case of overdose, gastric lavage and symptomatic therapy are indicated.

Pregnancy use

It is contraindicated for pregnant and breastfeeding women, since the safety of the drug has not been studied.

Similarities

Groprinosin, Isoprinosin

Additional information

Weight	0.405 kg
Shelf life	3 years. Shelf life after the first opening of the bottle – 3 months. Do not use after the expiry date specified on the package.
Conditions of storage	Store in the dark place at 15 to 25 ° C. Store out of the reach of children.
Manufacturer	ABC Pharmaciotici S.p.A., Italy
Medication form	syrup
Brand	ABC Pharmaciotici S.p.A.