Normase, 667 mg/ml syrup 200 ml

Active ingredient

Lactulose

Composition

In 100 ml of the drug contains:

• active ingredient:
• lactulose solution (in terms of lactulose) – 66.7 g
• excipients:
• citric acid -0.05 g,
• cream flavoring (#7 bis) -0.06 g,
• purified water – up to 100 ml.

Flavoring composition:
propylene glycol,
dihydrocoumarin,
vanillin.

How to take, the dosage

Lactulose solution can be taken either diluted or undiluted. It is necessary to swallow a single dose taken immediately, without retaining it in the mouth. All doses must be chosen individually.

In case of a single daily dose it should be taken at the same time, for example, during breakfast.
During the therapy with laxatives it is recommended to take a sufficient amount of liquid (1.5-2 liters, equal to 6-8 glasses) a day.
Dosage for the treatment of constipation or to soften the stool for medical purposes:

The daily dose of lactulose can be taken once or divided into two using a measuring cup.
The initial dose can be adjusted to a maintenance dose depending on the response to the drug intake. Therapeutical effect may appear 2-3 days after the receipt of the preparation.

In case of constipation: Adults: 15-40 ml per day in the first 3 days and then 10-25 ml. Children over 6 years old – 15 ml per day in the first 3 days and then 10 ml; 1-6 years old – 5-10 ml per day, up to 1 year old – 5 ml per day. Duration of treatment: from 4 weeks to 3-4 months.
In case of hepatic coma, precoma, encephalopathy and hyperammonemia: the initial dose is 30-60 ml 3 times a day. Then the dose is adjusted so that soft stools are 2-3 times a day. Treatment may last up to 3 months and more.

In case of dysbacteriosis and salmonellosis: adults – 15-30 ml 3-5 times a day, children over 8 years old – 45 ml per day, from 5 to 8 years old – 25 ml per day, from 1 to 5 years old – 15 ml per day, up to 1 year old 5-15 ml per day. The treatment course lasts 10 to 12 days. The course may be repeated three times with one-week intervals.
In the postoperative period the preparation is administered in adults in 10-30 ml 3 times a day, in children aged more than 1 year – in 5-10 ml 2-3 times a day, up to 1 year – in 5 ml two times a day. The drug is prescribed 18-24 hours after surgery for 3-5 days.

Interaction

In concomitant use antibiotics and antacids reduce the effectiveness of lactulose.

Lactulose alters pH-dependent release of enteric-soluble drugs.

It is not recommended to take lactulose within 2 hours after taking other drugs.

Special Instructions

If there is no therapeutic effect within a few days, a physician should be consulted.

Lactulose should be prescribed with caution in patients with lactose intolerance.
It should be noted that Normase® may contain small amounts of related sugars (e.g. lactose, galactose, epilactose and fructose).